Compare Humalog vs. Levemir

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Humalog (insulin lispro)

Prescription only

Levemir (insulin detemir)

Prescription only
Lowers blood sugar.

Humalog (insulin lispro) is a fast-acting insulin that controls blood sugar around meal times.

3.7/ 5 average rating with 280 reviewsforHumalog
Lowers blood sugar.

Levemir (insulin detemir) is an effective, long-acting insulin that provides all-day sugar control, but there are similar medications that can be used instead.

3.3/ 5 average rating with 130 reviewsforLevemir
Upsides
  • Humalog (insulin lispro) is the most effective medication for lowering your blood sugar.
  • Works quickly to control your sugar levels after meals.
  • Dose can be easily adjusted to create a regimen that's tailored to your body's needs.
  • Humalog (insulin lispro) can be used even if you have liver or kidney problems, unlike other anti-diabetic medications.
  • Insulin is the most effective blood sugar lowering medication, as it lowers A1c (average blood sugar over time) up to 2 or 3%. When used correctly, it'll prevent the harmful effects of high blood sugar levels on your organs and blood vessels.
  • Levemir (insulin detemir) is a long lasting insulin that provides consistent, all-day blood sugar control with less risk of low blood sugar.
  • Doses can be easily adjusted to make a customized regimen that's tailored to your body's needs.
  • Starting insulin early in the treatment of type 2 diabetes can maintain your body's insulin producing cells and slow down disease progression.
  • Levemir (insulin detemir) can be used in people with liver or kidney problems.
Downsides
  • You have to take Humalog (insulin lispro) by injection.
  • Humalog (insulin lispro) is likely to cause moderate weight gain (around 4 to 6 pounds).
  • There is a higher risk for episodes of low blood sugar compared to other anti-diabetic medications.
  • Effects do not last long enough to control your blood sugar for a whole day.
  • You have to take Levemir (insulin detemir) by injection.
  • You have to check your blood sugar regularly.
  • There is a risk of low blood sugar episodes with use of Levemir (insulin detemir).
  • Levemir (insulin detemir) can cause tiredness, moderate weight gain, and swelling in your hands, ankles, or feet.
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Used for
Dosage forms
  • Injection
  • Injection
Price
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Reviews
280 reviews so far
64%
saidit'sworth it
50%
saiditworked well
16%
saidit'sa big hassle

Have you used Humalog (insulin lispro)?

Leave a review
130 reviews so far
45%
saidit'sworth it
35%
saiditworked well
22%
saidit'sa big hassle

Have you used Levemir (insulin detemir)?

Leave a review
Side effects
The Humalog (insulin lispro) FDA package insert doesn’t have numbers about how common side effects are.
5possible side effects
  • Upper respiratory tract infection
    26%
  • Headache
    23%
  • Sore throat
    10%
  • Flu-like symptoms
    8%
  • Stomach pain
    6%
See more detailed side effects
Risks and risk factors
  • Life-threatening low blood sugar (hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medications
    • Poor injection techniques
  • Complications due to low potassium
    • Use of medications that lower potassium
    • Current electrolyte imbalance
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings
  • Life-threatening low blood sugar (Hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
  • Complications due to low potassium
    • Use of other medicine that lower potassium
    • Current electrolyte imbalance
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings