Compare Human Insulin vs. Novolog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Humulin (Human Insulin)

Prescription only

Novolog (insulin aspart)

Prescription only
Lowers blood sugar.

This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.

3.6/ 5 average rating with 57 reviewsforHuman Insulin
Lowers blood sugar.

Novolog (insulin aspart) is a fast-acting insulin that provides meal-time blood sugar control. For long-term control, you'll need to take Novolog (insulin aspart) with other medicines to keep your overall blood sugar down.

3.5/ 5 average rating with 177 reviewsforNovolog
Upsides
  • Some types of this medication are available without a prescription.
  • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
  • Available in different combinations so that you can do one shot or multiple shots a day.
  • When used correctly, this medication will l lower blood sugar every time you use it and prevent the harmful, long-term effects of high sugar levels on your organs and blood vessels.
  • You can easily change the dose of Novolog (insulin aspart) to fit your individual needs.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Can use Novolog (insulin aspart) even if you have liver or kidney problems, unlike many other blood sugar-lowering medicines.
Downsides
  • Has to be taken exactly as directed or it can cause high or low blood sugar.
  • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
  • Have to take insulin by injection.
  • Might have to check your blood sugar multiple times a day, usually before each meal.
  • Novolog (insulin aspart) is likely to cause moderate weight gain.
  • Higher risk of low blood sugar episodes compared to other kinds of diabetes medications.
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Used for
Dosage forms
  • Injection
  • Inhaler
  • Injection
Price
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Reviews
57 reviews so far
67%
saidit'sworth it
46%
saiditworked well
11%
saidit'sa big hassle

Have you used Humulin (Human Insulin)?

Leave a review
177 reviews so far
58%
saidit'sworth it
46%
saiditworked well
19%
saidit'sa big hassle

Have you used Novolog (insulin aspart)?

Leave a review
Side effects
The Humulin (Human Insulin) FDA package insert doesn’t have numbers about how common side effects are.
The Novolog (insulin aspart) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Changes in blood sugar
  • Changes in skin appearance
  • Weight gain
See more detailed risks and warnings
  • Life-threatening low blood sugar (Hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Changes in meal pattern or exercise
    • Kidney problems
    • Liver problems
  • Complications due to low potassium
    • Use of medications that lower potassium
    • Current imbalance of electrolytes
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings