Compare hydrochlorothiazide vs. Lisinopril
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Removes water from the body, which lowers blood pressure.
Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
●●●●●
3.3/ 5 average rating with 139 reviewsforhydrochlorothiazide
Lowers blood pressure.
Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.
●●●●●
3.8/ 5 average rating with 687 reviewsforLisinopril
Upsides
- Does a good job getting rid of extra fluids in your body by making you urinate more.
- A first-choice blood pressure treatment. Works especially well for people of African descent.
- Lowers the risk of heart attack and stroke.
- Good option if you have high blood pressure and heart failure.
- Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
- Can be good for patients with osteoporosis since it raises the body's level of calcium.
- A first-choice blood pressure treatment for many people.
- Lowers the risk of heart attack and stroke.
- Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
- Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
- Very cheap drug, and comes available as a liquid for children over 6 years of age.
Downsides
- Makes you urinate more often.
- Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
- It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
- People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
- Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
- Requires a yearly blood test to see how the medicine is affecting your body.
- Zestril (lisinopril) isn't safe to use if you're pregnant.
- Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
Used for
- High blood pressure
- Fluid retention (edema)
- High urine calcium
- Osteoporosis
- Diabetes insipidus from lithium
Dosage forms
- Pill
- Pill
- Liquid
Price
Lowest price
$112.57
Find instant savings near youLowest price
$497.46
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
139 reviews so far
47%
saidit'sworth it
31%
saiditworked well
16%
saidit'sa big hassle
Have you used Microzide (hydrochlorothiazide (HCTZ))?
Leave a review687 reviews so far
61%
saidit'sworth it
51%
saiditworked well
14%
saidit'sa big hassle
Have you used Zestril (lisinopril)?
Leave a reviewSide effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Dehydration and electrolyte imbalance
- Current electrolyte imbalance
- Lower kidney function
- Dehydration
- Severe allergic reactions
- History of sulfa allergies
- Gout
- History of gout
- Current kidney problems
- Vision problems
- History of sulfa or penicillin allergies
- Higher blood sugars
- Diabetes
- Harm to fetus
- Women of childbearing age
- Cough
- Swelling of face and head
- African descent
- High potassium
- Current kidney problems
- Medicines that increase potassium
- Use of salt substitutes
- Worsening kidney problems
- History of kidney problems
- Low blood pressure
- Taking with alcohol
- Taking other medicines that lower your blood pressure