Compare ibuprofen vs. Relafen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Advil (ibuprofen)

Over-the-counter

Relafen (nabumetone)

Prescription only
Relieves pain, fever, and swelling.

Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.

4.0/ 5 average rating with 892 reviewsforibuprofen
Relieves pain and inflammation.

Relafen (nabumetone) works well for relieving pain and inflammation, but may take up to a week to kick in.

Upsides
  • Advil (ibuprofen) is effective for treating fever, pain, and inflammation.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.
  • Advil (ibuprofen) causes less stomach problems than its alternatives.
  • It comes in different flavored liquid forms that makes it easy for children to take.
  • Relafen (nabumetone) is good for relieving pain and inflammation from osteoarthritis and rheumatoid arthritis.
  • Usually taken only once a day, while other NSAIDS need to be taken a few times a day for the same effect.
  • Relafen (nabumetone) causes less stomach upset and overall side effects than other NSAIDs, like ibuprofen and naproxen.
Downsides
  • Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.
  • Relafen (nabumetone) does not work as quickly as other NSAIDs.
  • Relafen (nabumetone), like other NSAIDS, is not safe for pregnant women and people who are age 60 or older.
  • Relafen (nabumetone) can cause serious complications including stomach bleeding and kidney problems if taken for a long period of time.
  • The safety and effectiveness of Relafen (nabumetone) for children are not known so they should not take it.
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Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Suspension
  • Pill
Price
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Reviews
892 reviews so far
88%
saidit'sworth it
52%
saiditworked well
4%
saidit'sa big hassle

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Side effects
The Advil (ibuprofen) FDA package insert doesn’t have numbers about how common side effects are.
3possible side effects
  • Diarrhea
    14%
  • Upset stomach
    13%
  • Stomach pain
    12%
See more detailed side effects
Risks and risk factors
  • Heart attack and stroke
    • History of heart problems
    • Taking Advil (ibuprofen) for a long period of time
  • Stomach bleeding
    • History of stomach bleeding
    • Age 60 or older
    • Taking aspirin, other NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Smoking
    • Taking the medicine for a long period of time
  • Severe allergic reaction
    • Asthma
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Kidney damage
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking certain high blood pressure medications
    • Age 60 or older
    • Taking the medicine for a long period of time
  • Harm to fetus (unborn baby)
    • Women who want to or can become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Heart attack and stroke
    • History of heart problems
    • Taking Relafen (nabumetone) for a long period of time
  • Stomach bleeding
    • History of stomach bleeding and/or ulcers
    • Age 60 or older
    • Taking aspirin, other NSAIDs, steroids, or blood thinners
    • Drinking alcoholic beverages
    • Smoking
    • Taking the medicine for a long period of time
    • People with poor general health
  • Severe allergic reaction
    • Asthma
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Kidney damage
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking certain high blood pressure medications
    • Age 60 or older
    • Taking the medicine for a long period of time
  • Harm to fetus
    • Pregnant women
    • Women who want to or can become pregnant
  • Heart-related complications
    • Recent heart surgery or heart attack
    • History of high blood pressure
    • History of heart failure
See more detailed risks and warnings