Compare Imodium vs. alosetron

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Imodium (Loperamide)


Lotronex (alosetron)

Prescription only
Treats diarrhea.

One day is too many days to have diarrhea. Having Imodium (Loperamide) on hand to relieve your symptoms can be a life-saver.

4.2/ 5 average rating with 285 reviewsforImodium
Reduces diarrhea in women with severe irritable bowel syndrome (IBS).

Lotronex (alosetron) is good add-on treatment for severe diarrhea in women with IBS, but shouldn't be used in men or those with constipation-dominant IBS.

  • Most people who take Imodium feel there's no hassle and it's definitely worth it!
  • Non-habit forming and available over-the-counter.
  • It comes in caplets, liquid, and chewable tablets so you can use it anywhere you need it.
  • Imodium is used for short-term, chronic and traveler's diarrhea. It's also used for people who have diarrhea caused by cancer or certain medicines that treat cancer.
  • Good alternative if nothing else has worked to control your diarrhea.
  • Has fewer side effects than other medicines used to treat diarrhea related to IBS.
  • Imodium only treats your diarrhea symptoms. Diarrhea may be caused by a number of conditions and will need specific treatment that deals with the underlying issue.
  • Studies in people taking Imodium for chronic diarrhea showed if the maximum number of doses didn't relieve symptoms in 10 days, then it probably won't work for that condition. You can talk to your doctor about other treatment options.
  • May be expensive if not covered by your insurance.
  • Only treats diarrhea in women with IBS. Not a good choice if you have constipation related to IBS or are a male with IBS.
Used for
  • Irritable bowel syndrome with severe diarrhea in women
Dosage forms
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
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285 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

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Side effects
1possible side effects
  • Constipation
See more detailed side effects
4possible side effects
  • Constipation
  • Stomach pain
  • Diarrhea
  • Hemorrhoid bleeding
See more detailed side effects
Risks and risk factors
  • Allergic reactions
    • Allergy to loperamide
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Liver problems
    • Current liver problems
  • Serious intestinal problems
    • Taking HIV medicines
    • Active infectious colitis
  • Risk to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Serious gastrointestinal problems
    • Daily doses higher than 1 mg
    • Constipation-predominant irritable bowel syndrome
See more detailed risks and warnings