Compare Remicade vs. Plaquenil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Remicade (infliximab)

Prescription only
Calms down your immune system.

Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.

4.0/ 5 average rating with 55 reviewsforRemicade
Treats malaria and autoimmune conditions including rheumatoid arthritis and lupus.

Plaquenil (hydroxychloroquine) is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs.

Upsides
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • Plaquenil (hydroxychloroquine) has been shown to improve physical function in up to 80% of patients with rheumatoid arthritis. Plaquenil (hydroxychloroquine) is commonly used for lupus in children because of less side effects compared to other medications.
  • Plaquenil (hydroxychloroquine) helps minimize joint damage. It can also decrease symptoms and future complications.
  • Plaquenil (hydroxychloroquine) is a good choice for people who have difficulty tolerating newer biologic medications.
  • A generic form of Plaquenil (hydroxychloroquine) is available.
Downsides
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
  • You will likely have to take additional medications to keep your rheumatoid arthritis in control.
  • Some people may develop eye problems, so you’ll have to get your eyes checked often.
  • Depending on what you're being treated for, it can take up to 6 months for the full benefits of Plaquenil (hydroxychloroquine).
  • Many people have nausea, stomach cramps, and diarrhea when they first start taking Plaquenil (hydroxychloroquine).
  • If you have heart, eye, liver conditions, or psoriasis, talk to your doctor to see if Plaquenil (hydroxychloroquine) is right for you.
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Used for
Dosage forms
  • Injection
  • Pill
Price
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Reviews
55 reviews so far
76%
saidit'sworth it
62%
saiditworked well
15%
saidit'sa big hassle

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Side effects
7possible side effects
  • Anemia
    11%
  • Low white blood cell count
    9%
  • Flushing
    9%
  • Viral infection
    8%
  • Bone fracture
    7%
  • Bacterial infection
    6%
  • Allergic reaction
    6%
See more detailed side effects
The Plaquenil (hydroxychloroquine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serious infections
    • Taking other immunosuppressant drugs
    • Age 65 or older
    • Comorbidities
  • Cancer
    • Taking other immunosuppressant drugs
    • History of malignancy
  • Heart failure
    • History of heart failure
    • Receiving higher doses
  • Nervous system effects
    • History of nerve problems
  • Lower blood cell counts
    • Ongoing or history of blood problems
  • Liver injury
See more detailed risks and warnings
  • Prescribing by Doctors
  • Drug resistance
  • Worsening of psoriasis
  • Pregnancy
    • Women of childbearing age
  • Damage to retina of eye
    • Higher doses
    • Kidney disease
    • Use for longer than 5 years
    • Current problems with vision
    • Use of certain drugs such as tamoxifen
  • Heart problems
    • Taking other medicines that cause disruptions in heart rhythm
    • Existing heart conditions
See more detailed risks and warnings