Compare Inspra vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Inspra (eplerenone)

Prescription only

Zestril (lisinopril)

Prescription only
Helps lower blood pressure and protect the heart in people with heart failure.

Inspra (eplerenone) lowers blood pressure and can help remove fluid when it's used with other drugs. It reduces the risk of death in people with heart failure and is usually used when people can't take spironolactone.

Lowers blood pressure.

Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.

3.8/ 5 average rating with 687 reviewsforLisinopril
Upsides
  • Lowers your blood pressure.
  • It can help remove fluid from your body when it's used with other drugs.
  • Reduces the risk of death in people with heart failure.
  • It can have fewer side effects than spironolactone.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
Downsides
  • Inspra (eplerenone) isn't a first choice medicine for lowering blood pressure or getting rid of fluid in the body. It's usually used in combination with other medicines.
  • It can make you feel dizzy for the first few days. Be careful driving until you know how it affects you.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
  • It can be very expensive compared to spironolactone.
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
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Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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687 reviews so far
61%
saidit'sworth it
51%
saiditworked well
14%
saidit'sa big hassle

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Side effects
2possible side effects
  • High potassium
    3%
  • Abnormal renal function
    3%
See more detailed side effects
1possible side effects
  • Low blood pressure
    5%
See more detailed side effects
Risks and risk factors
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
  • Heart problems from high potassium
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
    • Diabetes with proteinuria
  • Breast pain or swelling
  • Kidney problems
    • Current kidney problems
  • Liver problems
    • Liver damage
See more detailed risks and warnings
  • Harm to fetus
    • Women of childbearing age
  • Cough
  • Swelling of face and head
    • African descent
  • High potassium
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
  • Worsening kidney problems
    • History of kidney problems
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
See more detailed risks and warnings