Compare Invega vs. Clozaril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Invega (paliperidone)

Prescription only

Clozaril (clozapine)

Prescription only
Helps control your thoughts and mood.

Invega (paliperidone) relieves psychotic symptoms and improves mood.

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3.1/ 5 average rating with 34 reviewsforInvega
Helps control your thoughts and actions.

Clozaril (clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get regular blood work done because it can have very serious side effects.

Upsides
  • Won't make you as sleepy as other antipsychotic medicines.
  • If you have heart or kidney problems, this may be a better option than other antipsychotic medicines.
  • The pill and injection form allows for flexible dosing schedule.
  • Studies show that Clozaril (clozapine) effectively treats schizophrenia when other medications have failed. Clozaril (clozapine) also reduces risk of suicidal behavior.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Safer than other similar medicines during pregnancy.
  • Available as a generic, which is cheaper.
Downsides
  • Side-effects of weight gain and hormonal imbalance may be intolerable for younger patients.
  • Frequent blood tests are sometimes required to check how the medicine is affecting your body.
  • You need to get blood work done every time you get a prescription filled for Clozaril (clozapine). Once it is ready at the pharmacy, you need to pick it up within 7 days.
  • You can only get Clozaril (clozapine) at certain pharmacies that are registered to provide it.
  • You need to limit the amount of alcohol you drink while taking Clozaril (clozapine).
  • Clozaril (clozapine) can cause high blood sugar, high cholesterol, and weight gain.
  • May not be optimal for someone with a history of seizures.
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Used for
  • Schizophrenia
  • Suicidal behavior in schizophrenia
  • Psychosis in Parkinson's disease
Dosage forms
  • Pill
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
Price
Lowest price
$83.04
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Lowest price
$757.37
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Reviews
34 reviews so far
29%
saidit'sworth it
32%
saiditworked well
35%
saidit'sa big hassle

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Side effects
16possible side effects
  • Difficulty controlling movements
    12%
  • Drowsiness
    8%
  • Indigestion
    6%
  • Inability to be still
    6%
  • Nausea
    5%
  • Constipation
    4%
  • Weight gain
    4%
  • Abdominal discomfort
    3%
  • Common cold
    3%
  • Back pain
    3%
  • Fast heartbeat
    2%
  • Stomach upset
    2%
  • Upper respiratory tract infection
    2%
  • Decreased appetite
    2%
  • Increased appetite
    2%
  • Changes in speech
    2%
See more detailed side effects
31possible side effects
  • Drowsiness/sedation
    39%
  • Salivation
    31%
  • Fast heartbeat
    25%
  • Dizziness/vertigo
    19%
  • Constipation
    14%
  • Low blood pressure
    9%
  • Headache
    7%
  • Tremor
    6%
  • Fainting
    6%
  • Sweating
    6%
  • Dry mouth
    6%
  • Nausea
    5%
  • Vision problems
    5%
  • Fever
    5%
  • Disturbed sleep/nightmares
    4%
  • Restlessness
    4%
  • Loss of muscle movement
    4%
  • Agitation
    4%
  • High blood pressure
    4%
  • Stomach discomfort/heartburn
    4%
  • Weight gain
    4%
  • Seizures (convulsions)
    3%
  • Rigidity
    3%
  • Confusion
    3%
  • Nausea/vomiting
    3%
  • Low white blood cells
    3%
  • Fatigue
    2%
  • Trouble sleeping
    2%
  • Diarrhea
    2%
  • Problems urinating
    2%
  • Rash
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Higher blood sugar and cholesterol and weight gain
    • Diabetes
    • High cholesterol
  • Difficulty concentrating
    • Alcohol
    • Taking other medicines that make you less alert
  • Low blood pressure
See more detailed risks and warnings
  • Low white blood cells
  • Low blood pressure, slow heartbeat, and fainting
    • Dehydration
    • Taking blood pressure medications
    • Heart failure
  • Seizures
    • Seizure disorder
    • Alcohol abuse
  • Heart problems
    • History of heart problems
  • Increased risk of death in elderly with dementia
    • Over 65 with dementia
  • High blood sugar, high cholesterol, and weight gain
See more detailed risks and warnings
Learn more about Invega (paliperidone)
Learn more about Clozaril (clozapine)