Compare Invega vs. Rexulti

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Invega (paliperidone)

Prescription only

Rexulti (brexpiprazole)

Prescription only
Helps control your thoughts and mood.

Invega (paliperidone) relieves psychotic symptoms and improves mood.

●●●●●
3.1/ 5 average rating with 34 reviewsforInvega
Helps improve your mood and control your thoughts.

Rexulti (brexpiprazole) is an option for people with depression or schizophrenia but it can be more expensive than other medicines.

Upsides
  • Won't make you as sleepy as other antipsychotic medicines.
  • If you have heart or kidney problems, this may be a better option than other antipsychotic medicines.
  • The pill and injection form allows for flexible dosing schedule.
  • Rexulti (brexpiprazole) does not cause as much weight gain as other similar medications.
  • Fewer side effects compared to other similar medications.
Downsides
  • Side-effects of weight gain and hormonal imbalance may be intolerable for younger patients.
  • Frequent blood tests are sometimes required to check how the medicine is affecting your body.
  • Avaliable only as brand name and can be more expensive than other options. However, there may be programs to help with co-pays.
  • Rexulti (brexpiprazole) can cause restlessness, especially when you take higher doses and after a long period of time.
  • Can increase your cholesterol, blood sugar, and cause weight gain.
  • Elderly patients with dementia should not take Rexulti (brexpiprazole).
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Used for
Dosage forms
  • Pill
  • Injection
  • Pill
Price
Lowest price
$112.14
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Lowest price
$1234.89
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Reviews
34 reviews so far
29%
saidit'sworth it
32%
saiditworked well
35%
saidit'sa big hassle

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Side effects
16possible side effects
  • Difficulty controlling movements
    12%
  • Drowsiness
    8%
  • Indigestion
    6%
  • Inability to be still
    6%
  • Nausea
    5%
  • Constipation
    4%
  • Weight gain
    4%
  • Abdominal discomfort
    3%
  • Common cold
    3%
  • Back pain
    3%
  • Fast heartbeat
    2%
  • Stomach upset
    2%
  • Upper respiratory tract infection
    2%
  • Decreased appetite
    2%
  • Increased appetite
    2%
  • Changes in speech
    2%
See more detailed side effects
13possible side effects
  • Agitation
    9%
  • Weight gain
    7%
  • Headache
    7%
  • Sleepiness
    5%
  • Common cold
    4%
  • Tremors
    4%
  • Fatigue
    3%
  • Increased appetite
    3%
  • Dizziness
    3%
  • Anxiety
    3%
  • Restlessness
    3%
  • Constipation
    2%
  • Decreased cortisol
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Higher blood sugar and cholesterol and weight gain
    • Diabetes
    • High cholesterol
  • Difficulty concentrating
    • Alcohol
    • Taking other medicines that make you less alert
  • Low blood pressure
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
    • Under 24 years of age
  • Neuroleptic malignant syndrome
  • Difficulty controlling movements
    • Women over age 65
  • Higher blood sugar and cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
  • Risk of infection
See more detailed risks and warnings
Learn more about Invega (paliperidone)
Learn more about Rexulti (brexpiprazole)