Compare Invega vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Invega (paliperidone)

Prescription only

Saphris (asenapine)

Prescription only
Helps control your thoughts and mood.

Invega (paliperidone) relieves psychotic symptoms and improves mood.

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3.1/ 5 average rating with 34 reviewsforInvega
Treats bipolar disorder and schizophrenia.

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

Upsides
  • Won't make you as sleepy as other antipsychotic medicines.
  • If you have heart or kidney problems, this may be a better option than other antipsychotic medicines.
  • The pill and injection form allows for flexible dosing schedule.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides
  • Side-effects of weight gain and hormonal imbalance may be intolerable for younger patients.
  • Frequent blood tests are sometimes required to check how the medicine is affecting your body.
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
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Used for
Dosage forms
  • Pill
  • Injection
  • Dissolving pill
Price
Lowest price
$112.14
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Lowest price
$600.64
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Reviews
34 reviews so far
29%
saidit'sworth it
32%
saiditworked well
35%
saidit'sa big hassle

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Side effects
16possible side effects
  • Difficulty controlling movements
    12%
  • Drowsiness
    8%
  • Indigestion
    6%
  • Inability to be still
    6%
  • Nausea
    5%
  • Constipation
    4%
  • Weight gain
    4%
  • Abdominal discomfort
    3%
  • Common cold
    3%
  • Back pain
    3%
  • Fast heartbeat
    2%
  • Stomach upset
    2%
  • Upper respiratory tract infection
    2%
  • Decreased appetite
    2%
  • Increased appetite
    2%
  • Changes in speech
    2%
See more detailed side effects
10possible side effects
  • Sleepiness
    22%
  • Trouble sleeping
    10%
  • Difficulty controlling movements
    6%
  • Numbness in the mouth
    5%
  • Fatigue
    4%
  • Dizziness
    4%
  • Indigestion
    3%
  • Swelling in the arms and legs
    3%
  • Weight gain
    3%
  • High blood pressure
    3%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Higher blood sugar and cholesterol and weight gain
    • Diabetes
    • High cholesterol
  • Difficulty concentrating
    • Alcohol
    • Taking other medicines that make you less alert
  • Low blood pressure
See more detailed risks and warnings
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Difficulty controlling movements
  • Weight gain and diabetes
  • Changes in blood pressure and fainting
    • High blood pressure
    • History of heart disease
  • Higher risk of infection
See more detailed risks and warnings
Learn more about Invega (paliperidone)
Learn more about Saphris (asenapine)