Compare Invokamet vs. Glucovance
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Lowers blood sugar.
Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.
Lowers blood sugar.
Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.
Upsides
- Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
- Does not cause weight gain unlike other anti-diabetic medicines.
- Not as likely to cause hypoglycemia (low blood sugar)
- Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
- Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
- Can potentially lower your "bad cholesterol" levels.
- Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
Downsides
- Not a good option if you have worsening kidney function such as those age 65 years and up.
- May cause increased urination.
- More likely to cause broken bones and yeast and urinary tract infections.
- Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
- Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
- Not a good treatment option for those with kidney and/or liver problems.
- Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
- Can cause some weight gain.
Used for
Dosage forms
- Pill
- Pill
Price
Lowest price
$519.89
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$16.75
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Side effects
9possible side effects
- Yeast infection in women11%
- Urinary tract infections6%
- Increased urination5%
- Yeast infection in men4%
- Thirst3%
- Vaginal itching2%
- Constipation2%
- Nausea2%
- Abdominal pain2%
6possible side effects
- Upper respiratory infection17%
- Diarrhea17%
- Headache9%
- Nausea/vomiting8%
- Stomach pain7%
- Dizziness6%
Risks and risk factors
- Acid buildup in the blood
- Kidney problems
- Liver problems
- Congestive heart failure
- Contrast dye for procedure
- Surgery
- Alcohol use
- Low blood pressure (hypotension)
- Over age 65
- Kidney problems
- Diuretics
- Taking ACE inhibitors or ARBs
- Low blood pressure
- Bone fractures
- Low blood pressure
- Weak bones (Osteoporosis)
- Kidney damage
- History of kidney damage
- Heart failure
- Blood pressure medicines (water pills, ACE inhibitors, ACE inhibitors)
- Anti-inflammatories (NSAIDs)
- Genital yeast infection and urinary tract infection
- History of urinary tract infections
- History of fungal genital infections
- Uncircumcised males
- Low blood sugars
- Taking other diabetic medications
- Increased exercise
- Drinking alcohol
- Lactic acid build up in blood
- History of kidney problems
- History of liver problems
- Those with congestive heart failure
- Using contrast dye for procedures
- Undergoing surgery
- Drinking large amounts or frequent use of alcohol
- Serious heart problems
- Low blood sugar
- Skipping meals or having inconsistent meal times
- Drinking alcohol
- Using other blood sugar-lowering medicine
- People age 60 or older
- Those with kidney and/or liver problems
- Severe allergic reaction
- History of allergy to sulfa-containing medicine
- Breakdown of red blood cells
- People with G6PD deficiency