Compare Invokamet vs. Onglyza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood sugar.

Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.

Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Upsides
  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Not as likely to cause hypoglycemia (low blood sugar)
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
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Dosage forms
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Reviews
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Side effects
9possible side effects
  • Yeast infection in women
    11%
  • Urinary tract infections
    6%
  • Increased urination
    5%
  • Yeast infection in men
    4%
  • Thirst
    3%
  • Vaginal itching
    2%
  • Constipation
    2%
  • Nausea
    2%
  • Abdominal pain
    2%
See more detailed side effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Acid buildup in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use
  • Low blood pressure (hypotension)
    • Over age 65
    • Kidney problems
    • Diuretics
    • Taking ACE inhibitors or ARBs
    • Low blood pressure
  • Bone fractures
    • Low blood pressure
    • Weak bones (Osteoporosis)
  • Kidney damage
    • History of kidney damage
    • Heart failure
    • Blood pressure medicines (water pills, ACE inhibitors, ACE inhibitors)
    • Anti-inflammatories (NSAIDs)
  • Genital yeast infection and urinary tract infection
    • History of urinary tract infections
    • History of fungal genital infections
    • Uncircumcised males
  • Low blood sugars
    • Taking other diabetic medications
    • Increased exercise
    • Drinking alcohol
See more detailed risks and warnings
  • inflammation of the pancreas
    • Alcoholism
    • Elevated triglycerides
    • History of pancreatitis
    • Gallstones
  • Heart failure
    • History of heart failure
    • Bad kidney function
  • Low blood sugar (hypoglycemia)
    • Alcohol
    • Unexpected changes in diet
    • Changes in amount of exercise
    • Taking other anti-diabetic medications
  • Severe allergic reactions
  • Severe joint pain
  • Fluid-filled blisters on the skin (bullous pemphigoid)
See more detailed risks and warnings