Compare Invokana vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Invokana (canagliflozin)

Prescription only

Diabeta (glyburide)

Prescription only
Lowers blood sugar.

Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.

4.0/ 5 average rating with 27 reviewsforInvokana
Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

3.3/ 5 average rating with 110 reviewsforglyburide
Upsides
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
27 reviews so far
67%
saidit'sworth it
56%
saiditworked well
19%
saidit'sa big hassle

Have you used Invokana (canagliflozin)?

Leave a review
110 reviews so far
45%
saidit'sworth it
34%
saiditworked well
21%
saidit'sa big hassle

Have you used Diabeta (glyburide)?

Leave a review
Side effects
9possible side effects
  • Yeast infection in women
    11%
  • Urinary tract infections
    6%
  • Increased urination
    5%
  • Yeast infection in men
    4%
  • Thirst
    3%
  • Vaginal itching
    2%
  • Constipation
    2%
  • Nausea
    2%
  • Abdominal pain
    2%
See more detailed side effects
2possible side effects
  • Nausea and heartburn
    2%
  • Skin allergies
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of leg and foot amputations
    • History of amputations 
    • Peripheral vascular disease (narrowed blood vessels)
    • Nerve problems
    • Diabetic foot ulcers 
  • Kidney damage and low blood pressure
    • History of kidney damage
    • Heart failure
    • Blood pressure medicines (water pills, ACE inhibitors, ACE inhibitors)
    • Anti-inflammatories (NSAIDs)
  • Low blood sugar (hypoglycemia)
    • Taking medicines for diabetes
  • Genital yeast infection and urinary tract infection
  • Increased acid and ketones in the blood
    • Long periods of fasting
    • Alcohol abuse
    • Dehydration
    • History of pancreatitis
See more detailed risks and warnings
  • Low blood sugar
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
  • Severe allergic reactions
    • History of sulfa allergies
See more detailed risks and warnings