Compare Invokana vs. Lantus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT

Invokana (canagliflozin)

Prescription only

Lantus (insulin glargine)

Prescription only
Lowers blood sugar.

Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.

4.0/ 5 average rating with 27 reviewsforInvokana
Lowers blood sugar.

Lantus (insulin glargine) is an effective, long-acting insulin that provides all-day blood sugar control, but it can cause low blood sugar levels, so be sure to have a source of sugar nearby.

3.7/ 5 average rating with 584 reviewsforLantus
Upsides
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
  • Insulin is one of the most effective blood sugar-lowering medication and can lower your A1c (average blood sugar over time) by up to 2-3%.
  • Lantus (insulin glargine) is a long-lasting insulin that provides consistent, all-day sugar control with just once or twice daily dosing.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body's needs.
  • Lantus (insulin glargine) can be used with liver or kidney problems.
Downsides
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
  • You have to take insulin by injection.
  • You have to check your blood sugar regularly to assure your medications are working.
  • You may gain some weight, around 4-6 pounds.
  • You have to maintain a consistent schedule to avoid low blood sugar episodes. Dramatic changes in weight or meal patterns will require dose adjustments.
ADVERTISEMENT
Used for
Dosage forms
  • Pill
  • Injection
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
27 reviews so far
67%
saidit'sworth it
56%
saiditworked well
19%
saidit'sa big hassle

Have you used Invokana (canagliflozin)?

Leave a review
584 reviews so far
67%
saidit'sworth it
51%
saiditworked well
14%
saidit'sa big hassle

Have you used Lantus (insulin glargine)?

Leave a review
Side effects
9possible side effects
  • Yeast infection in women
    11%
  • Urinary tract infections
    6%
  • Increased urination
    5%
  • Yeast infection in men
    4%
  • Thirst
    3%
  • Vaginal itching
    2%
  • Constipation
    2%
  • Nausea
    2%
  • Abdominal pain
    2%
See more detailed side effects
19possible side effects
  • Upper respiratory tract infection
    28%
  • Swelling in the limbs
    20%
  • High blood pressure
    20%
  • Flu
    19%
  • Sinus infection
    19%
  • Cataracts
    18%
  • Inflammation of the airways
    15%
  • Joint pain
    14%
  • Pain in extremity
    13%
  • Back pain
    13%
  • Cough
    12%
  • Urinary tract infection
    11%
  • Diarrhea
    11%
  • Depression
    11%
  • Infection
    10%
  • Headache
    10%
  • Blood vessel disease
    7%
  • Retinal vein disorder
    6%
  • Injection site pain
    3%
See more detailed side effects
Risks and risk factors
  • Increased risk of leg and foot amputations
    • History of amputations 
    • Peripheral vascular disease (narrowed blood vessels)
    • Nerve problems
    • Diabetic foot ulcers 
  • Kidney damage and low blood pressure
    • History of kidney damage
    • Heart failure
    • Blood pressure medicines (water pills, ACE inhibitors, ACE inhibitors)
    • Anti-inflammatories (NSAIDs)
  • Low blood sugar (hypoglycemia)
    • Taking medicines for diabetes
  • Genital yeast infection and urinary tract infection
  • Increased acid and ketones in the blood
    • Long periods of fasting
    • Alcohol abuse
    • Dehydration
    • History of pancreatitis
See more detailed risks and warnings
  • Life-threatening low blood sugar (Hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
  • Complications due to low potassium
    • Use of other medicine that lower potassium
    • Current electrolyte imbalance
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings