Compare Isordil vs. digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lanoxin (digoxin)

Prescription only
Relieves chest pain.

Isosorbide dinitrate is good for chest pain, but you have to be able to stick to your dosing schedule or it won't work as well.

2.8/ 5 average rating with 46 reviewsforIsordil
Improves heart pumping.

Lanoxin (digoxin) is effective at treating heart failure symptoms, but it doesn't lower your risk of death compared to other heart failure medicines.

3.3/ 5 average rating with 70 reviewsfordigoxin
Upsides
  • Treats and prevents heart-related chest pain (angina) from the narrowing of heart blood vessels (coronary artery disease).
  • Lanoxin (digoxin) is used for abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
  • Lanoxin (digoxin) does not need dose adjustments with people with liver problems.
  • Lanoxin (digoxin) is available in a generic form.
  • Lanoxin (digoxin) can be taken once daily.
Downsides
  • You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.
  • Headaches are normal with this medicine and they go away as your body gets used to it, but they can be severe or not tolerable for some people.
  • Lanoxin (digoxin) relieves heart failure symptoms, but doesn't lower your risk of death. It's usually used together with other medicines that help lower the risk of death in heart failure.
  • Use of Lanoxin (digoxin) requires blood tests, especially during the first few weeks of treatment to monitor drug level in the body.
  • If your blood levels of Lanoxin (digoxin) are too high, it can be life threatening.
  • Lanoxin (digoxin) is usually not an option for people with kidney problems.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Liquid
Price
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Reviews
46 reviews so far
46%
saidit'sworth it
24%
saiditworked well
20%
saidit'sa big hassle

Have you used Isordil (Isosorbide Dinitrate)?

Leave a review
70 reviews so far
64%
saidit'sworth it
43%
saiditworked well
31%
saidit'sa big hassle

Have you used Lanoxin (digoxin)?

Leave a review
Side effects
The Isordil (Isosorbide Dinitrate) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Dizziness
    5%
  • Mental disturbances
    4%
  • Nausea
    3%
  • Diarrhea
    3%
  • Headache
    3%
  • Death
    3%
  • Increased heart rate
    2%
  • Vomiting
    2%
  • Rash
    2%
See more detailed side effects
Risks and risk factors
  • Low blood pressure
    • Age 65 years or older
    • Taking drugs for erectile dysfunction
    • Alcohol use
  • Tolerance
See more detailed risks and warnings
  • Irregular heartbeat
    • History of heart problems
    • Drug interactions
    • Wolff-Parkinson-White syndrome
  • Digoxin toxicity
    • Low body weight
    • Elderly (>65 years old)
    • Worsening kidney function
    • Electrolyte imbalances
  • Thyroid imbalance
    • Overactive or underactive thyroid
See more detailed risks and warnings