Compare Itraconazole vs. Vfend

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Sporanox (itraconazole)

Prescription only

Vfend (voriconazole)

Prescription only
Treats fungal infections.

Sporanox (itraconazole) is effective oral medication that treats many different kinds of fungal infections. However, it has the potential to interact with a lot of other medications and has a few serious but rare side effects.

Treats fungal infections.

Vfend (voriconazole) is effective at treating many different fungal infections, but it can cause blurry vision and make your eyes more sensitive to light.

Upsides
  • Sporanox (itraconazole) is effective in treating infections caused by many different types of fungi.
  • Available as a generic in the capsule form.
  • Sporanox (itraconazole) can be used by people who have kidney problems.
  • Vfend (voriconazole) is good for treating infections caused by many different types of fungi.
  • Available as a generic, and in both tablet and liquid form.
  • Vfend (voriconazole) is the antifungal drug of choice to treat Aspergillosis infection.
Downsides
  • The liquid solution is especially likely to cause stomach upset like nausea and diarrhea.
  • Sporanox (itraconazole) is not a good choice for simple fungal infections (like nail infections) in people who have congestive heart failure because it can cause high blood pressure and swelling of the limbs.
  • Sporanox (itraconazole) isn't absorbed in the same way by everyone. You'll likely need to get lab tests done to check on its levels in the blood.
  • Sporanox (itraconazole) can cause serious side effects like allergic reactions, liver toxicity, nerve pain, or hearing loss.
  • Sporanox (itraconazole) has a lot of drug interactions. Let your doctor or pharmacist know about all of the medications you're taking.
  • Vfend (voriconazole) can cause blurry vision and sensitity to bright lights.
  • Vfend (voriconazole) cannot be taken with food.
  • Your skin may become more sensitive to the sun while taking Vfend (voriconazole). Make sure to use sunscreen or wear protective layers.
  • Vfend (voriconazole) has a lot of drug interactions.
  • Vfend (voriconazole) isn't absorbed in the same way by everyone, so you'll probably need to get regular blood tests while taking it.
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Used for
  • Salvage therapy for invasive aspergillosis
  • Blastomycosis
  • Oropharyngeal and esophageal candidiasis
  • Histoplasmosis
  • Onychomycosis
  • Vulvovaginal candidiasis in HIV-infected patients
  • Coccidioidal meningitis in HIV-infected patients
  • Coccidioidal pneumonia in HIV-infected patients
  • Cryptococcosis in HIV-infected patients
  • Disseminated microsporidiosis in HIV-infected patients
  • Penicilliosis in HIV-infected patients
  • Aspergillosis
  • Candidemia
  • Candidiasis of the esophagus
  • Disseminated candidiasis
  • Mycosis
  • Allergic bronchopulmonary aspergillosis
  • Aspergillosis prophylaxis
  • Blastomycosis
  • Febrile neutropenia
  • Oropharyngeal candidiasis
  • Pulmonary aspergillosis
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
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Side effects
14possible side effects
  • Nausea
    11%
  • Rash
    9%
  • Vomiting
    5%
  • Swelling due to fluid retention
    4%
  • Headache
    4%
  • Diarrhea
    3%
  • Tiredness
    3%
  • Fever
    3%
  • Itching
    3%
  • High blood pressure
    3%
  • Lowered liver function
    3%
  • Abdominal pain
    2%
  • Dizziness
    2%
  • Low potassium
    2%
See more detailed side effects
11possible side effects
  • Abnormal vision
    19%
  • Fever
    6%
  • Nausea
    5%
  • Rash
    5%
  • Chills
    4%
  • Vomiting
    4%
  • Headache
    3%
  • Abnormal liver tests
    3%
  • Sensitivity to light
    2%
  • Fast heart rate
    2%
  • Hallucinations
    2%
See more detailed side effects
Risks and risk factors
  • Congestive Heart Failure
    • History of congestive heart failure
  • Drug interactions
  • Liver toxicity
  • Irregular heartbeat
    • Taking other medications that can produce an irregular heartbeat
  • Do not switch between the capsules or liquid forms
See more detailed risks and warnings
  • Liver problems
    • Blood disorder
    • Liver disease
  • Abnormal vision or eye sensitivity
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
  • Gallbladder problems
    • History of gallblader disease
    • People with severe kidney problems
  • Pancreas problems (pancreatitis)
  • Skin reaction to light
    • Children
See more detailed risks and warnings