Compare Jardiance vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Jardiance (empagliflozin)

Prescription only

Glucotrol (glipizide)

Prescription only
Lowers blood sugar.

Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.

Lowers blood sugar.

Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.

3.2/ 5 average rating with 332 reviewsforGlucotrol
Upsides
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
Downsides
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended release pill
Price
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Reviews
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332 reviews so far
50%
saidit'sworth it
32%
saiditworked well
19%
saidit'sa big hassle

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Side effects
9possible side effects
  • Low blood sugar
    40%
  • Urinary tract infection
    9%
  • Yeast infection in women
    5%
  • Elevated cholesterol levels
    4%
  • Head cold
    3%
  • Increased urination
    3%
  • Yeast infection in men
    3%
  • Joint pain
    2%
  • Nausea
    2%
See more detailed side effects
9possible side effects
  • Dizziness
    7%
  • Diarrhea
    5%
  • Nervousness
    4%
  • Tremor
    4%
  • Low blood sugar
    3%
  • Constipation
    3%
  • Passing gas
    3%
  • Nausea
    3%
  • Headache
    2%
See more detailed side effects
Risks and risk factors
  • Low blood pressure
    • Over age 65
    • Kidney disease
    • Taking blood pressure medications
  • Worsening kidney function
    • Dehydration
    • Poor baseline kidney function
    • Congestive heart failure
  • Too much acid in the blood
    • Type 1 diabetes
    • Extended fasting
  • Yeast infections and urinary tract infections
See more detailed risks and warnings
  • Serious heart problems
  • Low blood sugar
    • Skipping meals or having inconsistent meal times
    • Drinking alcohol
    • Using other blood sugar-lowering medicine
    • People age 60 or older
    • Those with kidney and/or liver problems
  • Severe allergic reaction
    • History of allergy to sulfa-containing medicine
  • Kidney and liver disease
    • Those with kidney and/or liver disease
  • Breakdown of red blood cells
    • People with G6PD deficiency
See more detailed risks and warnings