Compare Jardiance vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Jardiance (empagliflozin)

Prescription only

Glucophage (metformin)

Prescription only
Lowers blood sugar.

Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.

Lowers blood sugar.

Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.

3.7/ 5 average rating with 938 reviewsformetformin
Upsides
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
Downsides
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended release pill
  • Liquid
Price
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Reviews
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938 reviews so far
65%
saidit'sworth it
46%
saiditworked well
16%
saidit'sa big hassle

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Side effects
9possible side effects
  • Low blood sugar
    40%
  • Urinary tract infection
    9%
  • Yeast infection in women
    5%
  • Elevated cholesterol levels
    4%
  • Head cold
    3%
  • Increased urination
    3%
  • Yeast infection in men
    3%
  • Joint pain
    2%
  • Nausea
    2%
See more detailed side effects
7possible side effects
  • Diarrhea
    53%
  • Nausea/vomiting
    26%
  • Gas
    12%
  • Weakness
    9%
  • Indigestion
    7%
  • Stomach pain
    6%
  • Headache
    6%
See more detailed side effects
Risks and risk factors
  • Low blood pressure
    • Over age 65
    • Kidney disease
    • Taking blood pressure medications
  • Worsening kidney function
    • Dehydration
    • Poor baseline kidney function
    • Congestive heart failure
  • Too much acid in the blood
    • Type 1 diabetes
    • Extended fasting
  • Yeast infections and urinary tract infections
See more detailed risks and warnings
  • Excess lactic acid in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low vitamin B12 levels
See more detailed risks and warnings