Compare Keflex vs. Clindesse

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Keflex (cephalexin)

Prescription only

Clindesse (clindamycin)

Prescription only
Treats bacterial infections.

Keflex (cephalexin) is good for treating many bacterial infections, and is available as a generic.

3.7/ 5 average rating with 686 reviewsforKeflex
Treats bacterial vaginal infections with a single dose.

Clindesse (clindamycin) treats vaginal infections and is very easy to use.

Upsides
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Can be taken with or without food.
  • Generally few side effects compared with other antibiotics.
  • Very easy to use and works within a few days.
  • Generic available, so cost is lower.
  • Doesn't have many side effects.
  • You can stand up and walk around right after you use it, so you can use it at any time of day.
Downsides
  • Can cause diarrhea.
  • You may need to take Keflex (cephalexin) 2 to 4 times a day, which can be hard to remember.
  • If you're allergic to penicillins or other antibiotics, you might not be able to take this medicine.
  • Can cause yeast infections in some women.
  • After using Clindesse (clindamycin), must avoid sex and using tampons for 7 days.
  • Can very rarely cause severe diarrhea.
  • Cannot be used if you have bowel diseases like Crohn's disease or ulcerative colitis.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Cream
Price
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Reviews
686 reviews so far
64%
saidit'sworth it
48%
saiditworked well
14%
saidit'sa big hassle

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Side effects
The Keflex (cephalexin) FDA package insert doesn’t have numbers about how common side effects are.
5possible side effects
  • Yeast infection
    14%
  • Headache
    7%
  • Back pain
    5%
  • Constipation
    2%
  • Bladder infection
    2%
See more detailed side effects
Risks and risk factors
  • Diarrhea
  • New infections while taking Keflex (cephalexin)
    • Weakened immune system
    • Not taking Keflex (cephalexin) correctly
  • Allergic reaction
    • History of penicillin or cephalosporin allergies
See more detailed risks and warnings
  • Allergy alert
    • Known allergy to clindamycin
    • Known allergy to lincosamides
  • Severe diarrhea
    • History of Clostridium difficile-associated diarrhea
    • Crohn's disease
    • Ulcerative colitis
    • Regional enteritis
  • Weakened condoms and vaginal diaphragms
  • Safety in girls who haven't started puberty
See more detailed risks and warnings