Compare Ketoconazole vs. Diflucan

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Nizoral (Ketoconazole)

Prescription or OTC

Diflucan (fluconazole)

Prescription only
Treats fungal infections.

Nizoral (Ketoconazole) is a medication used on your skin to treat fungal infections; however, it takes several weeks for full recovery, and the directions are specific to each type of medication.

Treats yeast and other fungal infections.

Diflucan (fluconazole) is a cheap and effective treatment for fungal infections.

3.9/ 5 average rating with 30 reviewsforDiflucan
  • Recommended as a first choice medication to treat skin infections caused by fungi, including cradle cap, seborrheic dermatitis, and tinea versicolor.
  • Nizoral (Ketoconazole) isn't taken orally, so it doesn't cause liver issues.
  • Can be used with other medications to help control redness and swelling.
  • The 1% shampoo is available over-the-counter in the drugstore.
  • Available in a cheap generic version.
  • Single dose treatment for vaginal infections.
  • Available as a pill, liquid, or injection.
  • The foams (Extina and Ketodan) and gel (Xolegel) are only available as brand name and can be more expensive.
  • The 2.5% shampoo and creams are available only by prescription, but are generic.
  • The shampoo has to be left on for at least 5-10 minutes after lathering before you rinse it off.
  • It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color.
  • The fungal infections can be confused for other skin infections, so if Nizoral (Ketoconazole) doesn't work, it could be caused by another skin problem.
  • Excessive use of alcohol while on this medicine can harm your liver.
  • Can interfere with how other medicines work, especially birth control pills.
Used for
Dosage forms
  • Pill
  • Cream, gel, or ointment
  • Foam
  • Shampoo
  • Pill
  • Liquid
  • Injection
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30 reviews so far
saidit'sworth it
saiditworked well
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Side effects
1possible side effects
  • Any side effect
See more detailed side effects
4possible side effects
  • Headache
  • Nausea
  • Abdominal pain
  • Diarrhea
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Risks and risk factors
  • Severe allergic reactions
    • Asthma
See more detailed risks and warnings
  • Liver disease
  • Serious immediate allergic reaction
  • Skin rash
  • Use in pregnancy
See more detailed risks and warnings