Compare Ketoconazole vs. Noxafil

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Nizoral (Ketoconazole)

Prescription or OTC

Noxafil (posaconazole)

Prescription only
Treats fungal infections.

Nizoral (Ketoconazole) is a medication used on your skin to treat fungal infections; however, it takes several weeks for full recovery, and the directions are specific to each type of medication.

Treats and prevents fungal infections.

Noxafil (posaconazole) works against many different fungal infections, but may require close follow-up for potential side effects and drug interactions.

  • Recommended as a first choice medication to treat skin infections caused by fungi, including cradle cap, seborrheic dermatitis, and tinea versicolor.
  • Nizoral (Ketoconazole) isn't taken orally, so it doesn't cause liver issues.
  • Can be used with other medications to help control redness and swelling.
  • The 1% shampoo is available over-the-counter in the drugstore.
  • Noxafil (posaconazole) works against more types of fungal infections than other medications like it.
  • Available in liquid form if you have difficulty swallowing pills.
  • The foams (Extina and Ketodan) and gel (Xolegel) are only available as brand name and can be more expensive.
  • The 2.5% shampoo and creams are available only by prescription, but are generic.
  • The shampoo has to be left on for at least 5-10 minutes after lathering before you rinse it off.
  • It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color.
  • The fungal infections can be confused for other skin infections, so if Nizoral (Ketoconazole) doesn't work, it could be caused by another skin problem.
  • Available as brand version only so may be more expensive than other medications like it.
  • Noxafil (posaconazole) has many drug interactions.
  • The pill and liquid forms are not readily interchangeable without your doctor's help.
Used for
  • Prevention of fungal infection.
  • Treatment of fungal infection in the mouth or throat
Dosage forms
  • Pill
  • Cream, gel, or ointment
  • Foam
  • Shampoo
  • Extended release pill
  • Liquid
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Side effects
1possible side effects
  • Any side effect
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16possible side effects
  • Diarrhea
  • Nausea
  • Headache
  • Vomiting
  • Fever
  • Abdominal pain
  • Low white blood cells
  • Fatigue
  • Herpes simplex
  • Lung infection
  • Coughing
  • Rash
  • Anorexia
  • Weakness
  • Low red blood cells
  • Increased sweating
See more detailed side effects
Risks and risk factors
  • Severe allergic reactions
    • Asthma
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  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
  • Liver problems
    • Blood disorder
    • Liver disease
  • Kidney problems
    • Kidney problems
    • Kidney disease
  • Drug toxicity
See more detailed risks and warnings