Compare Ketoconazole vs. Vfend

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Nizoral (Ketoconazole)

Prescription or OTC

Vfend (voriconazole)

Prescription only
Treats fungal infections.

Nizoral (Ketoconazole) is a medication used on your skin to treat fungal infections; however, it takes several weeks for full recovery, and the directions are specific to each type of medication.

Treats fungal infections.

Vfend (voriconazole) is effective at treating many different fungal infections, but it can cause blurry vision and make your eyes more sensitive to light.

  • Recommended as a first choice medication to treat skin infections caused by fungi, including cradle cap, seborrheic dermatitis, and tinea versicolor.
  • Nizoral (Ketoconazole) isn't taken orally, so it doesn't cause liver issues.
  • Can be used with other medications to help control redness and swelling.
  • The 1% shampoo is available over-the-counter in the drugstore.
  • Vfend (voriconazole) is good for treating infections caused by many different types of fungi.
  • Available as a generic, and in both tablet and liquid form.
  • Vfend (voriconazole) is the antifungal drug of choice to treat Aspergillosis infection.
  • The foams (Extina and Ketodan) and gel (Xolegel) are only available as brand name and can be more expensive.
  • The 2.5% shampoo and creams are available only by prescription, but are generic.
  • The shampoo has to be left on for at least 5-10 minutes after lathering before you rinse it off.
  • It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color.
  • The fungal infections can be confused for other skin infections, so if Nizoral (Ketoconazole) doesn't work, it could be caused by another skin problem.
  • Vfend (voriconazole) can cause blurry vision and sensitity to bright lights.
  • Vfend (voriconazole) cannot be taken with food.
  • Your skin may become more sensitive to the sun while taking Vfend (voriconazole). Make sure to use sunscreen or wear protective layers.
  • Vfend (voriconazole) has a lot of drug interactions.
  • Vfend (voriconazole) isn't absorbed in the same way by everyone, so you'll probably need to get regular blood tests while taking it.
Used for
  • Aspergillosis
  • Candidemia
  • Candidiasis of the esophagus
  • Disseminated candidiasis
  • Mycosis
  • Allergic bronchopulmonary aspergillosis
  • Aspergillosis prophylaxis
  • Blastomycosis
  • Febrile neutropenia
  • Oropharyngeal candidiasis
  • Pulmonary aspergillosis
Dosage forms
  • Pill
  • Cream, gel, or ointment
  • Foam
  • Shampoo
  • Pill
  • Liquid
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Side effects
1possible side effects
  • Any side effect
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11possible side effects
  • Abnormal vision
  • Fever
  • Nausea
  • Rash
  • Chills
  • Vomiting
  • Headache
  • Abnormal liver tests
  • Sensitivity to light
  • Fast heart rate
  • Hallucinations
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Risks and risk factors
  • Severe allergic reactions
    • Asthma
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  • Liver problems
    • Blood disorder
    • Liver disease
  • Abnormal vision or eye sensitivity
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
  • Gallbladder problems
    • History of gallblader disease
    • People with severe kidney problems
  • Pancreas problems (pancreatitis)
  • Skin reaction to light
    • Children
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