Compare Lamictal vs. Depakote
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Prevents seizures and stabilizes mood.
Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.
●●●●●
3.7/ 5 average rating with 184 reviewsforLamictal
Treats and prevents seizures, and stabilizes mood.
Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.
●●●●●
3.3/ 5 average rating with 97 reviewsforDepakote
Upsides
- Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
- Works best for partial, tonic-clonic, and absence seizures.
- A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
- Doesn't require routine blood tests.
- Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
- Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
- Depakote (divalproex) is helpful for preventing frequent migraines.
- The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
- Depakote (divalproex) is available as a generic.
Downsides
- Can cause double vision, dizziness, sleepiness, and headache.
- Has the risk of a rare but life-threatening rash.
- Can make hormonal birth control less effective.
- Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
- It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
- Depakote (divalproex) is not a good medication for people with liver problems.
- Requires regular blood tests to see how the medication is affecting your body.
- Depakote (divalproex) can make you bleed more easily.
Used for
Dosage forms
- Pill
- Extended release
- Chewable tablet
- Dissolving tablet
- Pill
- Extended release pill
- Delayed release pill
Price
Lowest price
$78.22
Find instant savings near youLowest price
$28.70
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
184 reviews so far
66%
saidit'sworth it
58%
saiditworked well
18%
saidit'sa big hassle
Have you used Lamictal (Lamotrigine)?
Leave a review97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle
Have you used Depakote (divalproex)?
Leave a reviewSide effects
36possible side effects
- Dizziness38%
- Headache28%
- Diplopia28%
- Ataxia22%
- Nausea19%
- Blurred vision16%
- Somnolence14%
- Rhinitis14%
- Pharyngitis10%
- Rash10%
- Vomiting9%
- Cough increased8%
- Flu syndrome7%
- Dysmenorrhea7%
- Fever6%
- Diarrhea6%
- Incoordination6%
- Insomnia6%
- Abdominal pain5%
- Dyspepsia5%
- Constipation4%
- Tremor4%
- Depression4%
- Anxiety4%
- Vaginitis4%
- Convulsion3%
- Irritability3%
- Speech disorder3%
- Pruritus3%
- Vision abnormality3%
- Neck pain2%
- Reaction aggravated (seizure exacerbation)2%
- Anorexia2%
- Arthralgia2%
- Concentration disturbance2%
- Amenorrhea2%
9possible side effects
- Nausea22%
- Sleepiness19%
- Dizziness12%
- Vomiting12%
- Accidental injury11%
- Feeling weak10%
- Abdominal pain9%
- Upset stomach9%
- Rash6%
Risks and risk factors
- Suicidal thoughts or behavior
- History of depression
- Serious skin rash
- People also taking Depakote
- Taking more than the prescribed dose
- Increasing the dose too quickly
- Serious allergic reactions
- Blood disorders
- Meningitis
- Interactions with birth control pills
- Taking birth control pills
- Withdrawal seizures
- Stopping Lamictal (Lamotrigine) suddenly
- Harm to fetus
- Liver damage
- Children under age 2
- History of metabolic disorders
- Severe seizure disorder
- Brain disease
- History of liver problems
- Pancreas problems
- Suicidal thoughts or behavior
- History of depression
- Increased bleeding
- Mental changes
- History of metabolic disorders
- People also taking Topamax