Compare Lamictal vs. Topamax
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Prevents seizures and stabilizes mood.
Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.
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3.7/ 5 average rating with 184 reviewsforLamictal
Prevents seizures and migraine headaches.
Topamax (topiramate) is very effective at preventing many types of seizures and migraines, but it can cause several severe side effects that can lead to stopping the medication.
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3.3/ 5 average rating with 56 reviewsforTopamax
Upsides
- Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
- Works best for partial, tonic-clonic, and absence seizures.
- A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
- Doesn't require routine blood tests.
- Can lower your number of seizures and also prevent migraine headaches. This medicine can be used on its own or with other antiepileptic medicines to lower the frequency of seizures.
- Doesn't need routine blood tests like similar medications.
- Available in short-acting and long-acting forms.
- Comes as a generic, so it's relatively cheap.
Downsides
- Can cause double vision, dizziness, sleepiness, and headache.
- Has the risk of a rare but life-threatening rash.
- Can make hormonal birth control less effective.
- Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
- Can cause many severe side effects. People starting Topamax (topiramate) need to be monitored for these effects as soon as they start treatment.
- This medicine can take 4 to 6 weeks for the full effects of this medication to kick in, especially for people taking it for migraines.
- Children taking Topamax (topiramate) for long periods of time need to have their dose adjusted by their pediatrician as they grow.
- At higher doses (ie. 400 mg/day), children may experience difficulty with concentration/attention, fever, flushing, and confusion.
Used for
- Seizures
- Migraine prevention
- Alcoholism
- Essential tremors
- Eating disorder
Dosage forms
- Pill
- Extended release
- Chewable tablet
- Dissolving tablet
- Pill
- Extended release capsule
Price
Lowest price
$78.22
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$136.75
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Reviews
184 reviews so far
66%
saidit'sworth it
58%
saiditworked well
18%
saidit'sa big hassle
Have you used Lamictal (Lamotrigine)?
Leave a review56 reviews so far
52%
saidit'sworth it
50%
saiditworked well
36%
saidit'sa big hassle
Have you used Topamax (topiramate)?
Leave a reviewSide effects
36possible side effects
- Dizziness38%
- Headache28%
- Diplopia28%
- Ataxia22%
- Nausea19%
- Blurred vision16%
- Somnolence14%
- Rhinitis14%
- Pharyngitis10%
- Rash10%
- Vomiting9%
- Cough increased8%
- Flu syndrome7%
- Dysmenorrhea7%
- Fever6%
- Diarrhea6%
- Incoordination6%
- Insomnia6%
- Abdominal pain5%
- Dyspepsia5%
- Constipation4%
- Tremor4%
- Depression4%
- Anxiety4%
- Vaginitis4%
- Convulsion3%
- Irritability3%
- Speech disorder3%
- Pruritus3%
- Vision abnormality3%
- Neck pain2%
- Reaction aggravated (seizure exacerbation)2%
- Anorexia2%
- Arthralgia2%
- Concentration disturbance2%
- Amenorrhea2%
39possible side effects
- Sleepiness26%
- Loss of appetite24%
- Fatigue16%
- Injury14%
- Nervousness14%
- Personality disorder (behavior problems)11%
- Difficulty with concentration/attention10%
- Weight loss9%
- Aggressive reaction9%
- Abnormal gait8%
- Purpura8%
- Difficulty sleeping8%
- Viral infection7%
- Impaired coordination6%
- Nausea6%
- Increased saliva6%
- Muscle spasm5%
- Constipation5%
- Difficulty with memory5%
- Pneumonia5%
- Dizziness4%
- Speech disorders/ related speech problems4%
- Nose bleed4%
- Confusion4%
- Urinary incontinence4%
- Stomach flu3%
- Psychomotor slowing3%
- Skin disorder3%
- Allergic reaction2%
- Abnormal reflexes2%
- Thirst2%
- Pussing2%
- Hair loss2%
- Dermatitis2%
- Increased hair growth2%
- Red skin rash2%
- Eye abnormality2%
- Abnormal vision2%
- Leukopenia2%
Risks and risk factors
- Suicidal thoughts or behavior
- History of depression
- Serious skin rash
- People also taking Depakote
- Taking more than the prescribed dose
- Increasing the dose too quickly
- Serious allergic reactions
- Blood disorders
- Meningitis
- Interactions with birth control pills
- Taking birth control pills
- Withdrawal seizures
- Stopping Lamictal (Lamotrigine) suddenly
- Suicidal thoughts or behavior
- History of depression
- Fever and inability to sweat
- Children
- Mental and cognitive changes
- History of metabolic disorders
- People also taking Depakote
- Kidney stones
- Low-carb diet
- Dehydration
- Drug interactions
- Vision problems
- Withdrawal seizures
- Stopping Topamax (topiramate) suddenly