Compare Lexapro vs. Effexor
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Improves mood and helps you relax.
Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.
●●●●●
3.6/ 5 average rating with 1063 reviewsforLexapro
Improves mood and helps you relax.
Effexor (venlafaxine) is good for treating depression and anxiety, but it can cause more withdrawal symptoms if you stop suddenly compared to other antidepressants.
●●●●●
3.7/ 5 average rating with 577 reviewsforEffexor
Upsides
- Effective at relieving depression and anxiety symptoms.
- Lowers the likelihood that your depression will come back.
- Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
- Effexor (venlafaxine) effectively treats depression, anxiety, and panic disorder.
- Effexor (venlafaxine) causes more sleepiness than other antidepressants, so it's beneficial for people who have trouble sleeping.
- Effexor (venlafaxine) might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood.
- Effexor (venlafaxine) has several uses, which may be good for people with multiple conditions.
- Effexor (venlafaxine) is available in generic, which is cheaper.
Downsides
- Can cause a small weight gain of 1-5 pounds.
- Lexapro (escitalopram) is not a good option if you have heart or liver problems.
- The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
- Effexor (venlafaxine) can cause side effects such as decreased libido and increased blood pressure.
- Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people aged 24 years or younger.
- Compared to other antidepressants, it's more likely to cause unpleasant withdrawal symptoms if you suddenly stop taking it and can causes more sleepiness.
Used for
Dosage forms
- Pill
- Liquid
- Pill
- Extended release
Price
Lowest price
$7.21
Find instant savings near youLowest price
$12.87
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
1063 reviews so far
61%
saidit'sworth it
48%
saiditworked well
15%
saidit'sa big hassle
Have you used Lexapro (escitalopram)?
Leave a review577 reviews so far
62%
saidit'sworth it
51%
saiditworked well
23%
saidit'sa big hassle
Have you used Effexor (venlafaxine)?
Leave a reviewSide effects
25possible side effects
- Headache24%
- Nausea18%
- Problems ejaculating14%
- Sleepiness13%
- Insomnia12%
- Dry mouth9%
- Diarrhea8%
- Fatigue8%
- Decreased libido7%
- Problems with orgasm6%
- Constipation5%
- Flu-like symptoms5%
- Increased sweating4%
- Indigestion3%
- Vomiting3%
- Neck/shoulder pain3%
- Abnormal dreams3%
- Decrease appetite3%
- Lack of energy3%
- Tingling or burning in the hands/feet2%
- Abdominal pain2%
- Flatulence2%
- Toothache2%
- Yawning2%
- Menstrual disorder2%
39possible side effects
- Nausea37%
- Headache25%
- Drowsiness23%
- Dry mouth22%
- Dizziness19%
- Difficulty sleeping18%
- Constipation15%
- Nervousness13%
- Weakness12%
- Sweating12%
- Abnormal ejaculation/orgasm12%
- Loss of appetite11%
- Diarrhea8%
- Infection6%
- Vomiting6%
- Anxiety6%
- Blurred vision6%
- Impotence6%
- Indigestion5%
- Tremor5%
- Abnormal dreams4%
- Chills3%
- Rash3%
- Gas3%
- Stiff muscles3%
- Prickling/burning sensation3%
- Yawn3%
- Increased urination3%
- Chest pain2%
- Trauma2%
- Increased blood pressure2%
- Increased heart rate2%
- Decreased libido2%
- Agitation2%
- Confusion2%
- Thinking abnormal2%
- Changes in taste2%
- Ringing in the ears2%
- Dilation of pupils2%
Risks and risk factors
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Using other medications that affect serotonin
- Withdrawal
- Stopping Lexapro (escitalopram) suddenly
- Increased bleeding
- Taking blood thinners
- Sexual problems
- Uncovering of bipolar disorder
- Bipolar disorder
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
- Withdrawal
- Stopping Effexor (venlafaxine) suddenly
- Increased bleeding
- Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
- Increased blood pressure
- Bipolar disorder
- History of bipolar disorder
- At risk for bipolar disorder