Compare lidocaine vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats nerve pain.

Lidoderm (lidocaine) works well to treat nerve pain that is localized to a small area, but its topical application may cause minor skin irritation.

4.2/ 5 average rating with 18 reviewsforlidocaine
Treats tingling and burning nerve pain.

Neurontin (gabapentin) is an old seizure disorder medicine that is now used to treat nerve-related pain caused by different conditions.

3.4/ 5 average rating with 620 reviewsforNeurontin
Upsides
  • Minimal side-effects compared to other pain relievers since it works locally at the site of application.
  • Won't hurt your kidneys or liver unlike other pain relievers.
  • Available in many different topical formulations to fit your needs.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
Downsides
  • Application may cause minor stinging or burning skin irritation.
  • Used patches requires proper medication disposal since it still contain enough medicine to be dangerous to children and pets.
  • Not a good choice if you've had allergic reactions to numbing medications (local anesthetics) or have a history of irregular heartbeats.
  • Neurontin (gabapentin) can cause some side effects, including memory problems, drowsiness, dizziness, or confusion. There is a higher risk for these side effects if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • You can't skip or miss doses since suddenly stopping Neurontin (gabapentin) can cause seizures.
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Used for
Dosage forms
  • Cream
  • Gel
  • Ointment
  • Jelly
  • Spray
  • Patch
  • Lotion
  • Topical solution
  • Pill
  • Oral solution
  • Extended release
Price
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Reviews
18 reviews so far
67%
saidit'sworth it
72%
saiditworked well
22%
saidit'sa big hassle

Have you used Lidoderm (lidocaine)?

Leave a review
620 reviews so far
57%
saidit'sworth it
40%
saiditworked well
19%
saidit'sa big hassle

Have you used Neurontin (gabapentin)?

Leave a review
Side effects
The Lidoderm (lidocaine) FDA package insert doesn’t have numbers about how common side effects are.
20possible side effects
  • Dizziness
    28%
  • Drowsiness
    21%
  • Swelling in the limbs
    8%
  • Abnormal physical weakness
    6%
  • Diarrhea
    6%
  • Infection
    5%
  • Dry mouth
    5%
  • Constipation
    4%
  • Nausea
    4%
  • Headache
    3%
  • Accidental injury
    3%
  • Stomach pain
    3%
  • Vomiting
    3%
  • Worse coordination
    3%
  • Thinking abnormal
    3%
  • Decreased vision
    3%
  • Gas
    2%
  • Weight gain
    2%
  • Abnormal gait
    2%
  • Lack of coordination
    2%
See more detailed side effects
Risks and risk factors
  • Overdose
    • Use of heating pad on skin
    • Applying patch to red, irritated or broken skin
    • Leaving patch on for more than 12 hours
    • Using patch on a very large area
    • Older age
    • Smaller patients
    • Liver disease
  • Accidental poisoning
    • Not disposing of Lidoderm (lidocaine) correctly
  • Eye irritation
    • Not washing hands after touching or applying Lidoderm (lidocaine)
  • Skin reactions
    • Applying Lidoderm (lidocaine) to warm skin
    • Covering patch with wrap or heating pad
  • Heart problems
    • History of heart problems
    • Using Lidoderm (lidocaine) with medications to treat irregular heartbeat
See more detailed risks and warnings
  • Suicidal thoughts or behavior
  • Neurologic and psychiatric side effects (children)
    • Children ages 3 to 12
  • Serious allergic reaction and multiple organ problems
  • Driving impairment
    • Taking Neurontin (gabapentin) with alcohol
    • Taking other medicines that cause dizziness and/or drowsiness
  • Withdrawal seizures
    • Stopping Neurontin (gabapentin) suddenly
See more detailed risks and warnings