Compare Lithium vs. Latuda

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Lithobid (Lithium)

Prescription only

Latuda (lurasidone)

Prescription only
Stabilizes mood.

Lithobid (Lithium) is the most effective long-term treatment for bipolar disorder, but it comes with a lot of side effects, so it can be difficult to take.

Helps control your thoughts and mood.

Latuda (lurasidone) is good for treating schizophrenia and depression related to bipolar disorder, but can cause sleepiness and movement disorders that can affect your ability to stay alert.

3.8/ 5 average rating with 61 reviewsforLatuda
  • A first-line, long-term treatment for bipolar disorder. Effective at stabilizing mood and preventing relapse.
  • For manic episodes (acute mania), more effective when taken together with an antipsychotic medicine.
  • The only drug proven (so far) to lower the risk of suicide, possibly because it lowers aggressiveness and impulsivity.
  • Has been shown in clinical studies to help people experience improvement in their thoughts and mood.
  • Can be taken alone or with other medications that manage your mood.
  • Compared to other antipsychotic medicines, Latuda (lurasidone) has a lower risk of causing weight gain, high cholesterol, high blood sugar, and heart rhythm changes.
  • Has many short- and long-term side effects.
  • The dose for it to work well is very close to the amount that causes overdose, so you have to be careful, watch out for symptoms, and get help immediately if you accidentally take too much.
  • Probably not safe if you have kidney problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • It may take several weeks before you feel the full effects of Latuda (lurasidone).
  • You may get more side effects if you're taking certain antifungal and heart medicines.
  • Can cause you to be more sensitive to heat and make it harder for your body to cool off.
  • Need to avoid drinking alcohol while taking Latuda (lurasidone).
Used for
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Pill
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61 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

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Side effects
The Lithobid (Lithium) FDA package insert doesn’t have numbers about how common side effects are.
12possible side effects
  • Nausea
  • Sleepiness
  • Restlessness
  • Movement disorder
  • Dry mouth
  • Vomiting
  • Diarrhea
  • Common cold
  • Anxiety
  • Flu
  • Urinary tract infection
  • Back pain
See more detailed side effects
Risks and risk factors
  • Overdose
    • Low sodium
    • Dehydration
    • Drug interactions (diuretics, ACE inhibitors, NSAIDs like ibuprofen)
  • Pregnancy
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
  • Reduced kidney function
    • Long-term use
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
  • Abnormal and involuntary muscle movements
    • Taking Latuda (lurasidone) in higher doses or for a long time
    • Elderly
    • Female
  • Low blood pressure
    • Dehydration
    • Taking blood pressure medications
  • Sedation and driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Low white blood cells
See more detailed risks and warnings