Compare Lodine vs. Arthrotec

Head-to-head comparisons of medication uses, side effects, ratings, and more.

No information currently available
Treats arthritis pain and swelling.

Arthrotec (Diclofenac / Misoprostol) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, it's recommended to limit the amount you take.

No information currently available
  • Clinical studies show that Arthrotec (Diclofenac / Misoprostol) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
No information currently available
  • Can't be used in pregnant or breastfeeding women.
  • You should avoid alcohol while on Arthrotec (Diclofenac / Misoprostol) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
Used for
  • Juvenile rheumatoid arthritis Osteoarthritis Pain Rheumatoid arthritis
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Extended release
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Side effects
The Lodine (Etodolac) FDA package insert doesn’t have numbers about how common side effects are.
6possible side effects
  • Abdominal pain
  • Diarrhea
  • Dyspepsia
  • Nausea
  • GI disorders
  • Flatulence
See more detailed side effects
Risks and risk factors
No information currently available
  • Heart attack or stroke
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking
  • Stomach bleeding
    • History of stomach bleeding or ulcers
    • Age 65 years or older
  • Bruising or bleeding
    • Hemophilia
    • von Willebrand's disease
    • Low blood platelet count
    • Also taking an anticoagulant medication
  • Serious allergic reactions
    • Asthma
    • Rhinitis
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Lowers kidney function
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking diuretics
    • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
    • Age 65 or older
  • Increased blood pressure
    • History of high blood pressure
    • Taking water pills (diuretics)
  • Harm to unborn babies
    • Late pregnancy (more than 30 weeks)
See more detailed risks and warnings