Compare Lomotil vs. Imodium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stops diarrhea.

Lomotil (diphenoxylate / atropine) is very effective at stopping diarrhea, but shouldn't be used for all types of diarrhea.

Treats diarrhea.

One day is too many days to have diarrhea. Having Imodium (Loperamide) on hand to relieve your symptoms can be a life-saver.

4.2/ 5 average rating with 285 reviewsforImodium
  • Available as a cheaper, generic form.
  • Available in both liquid and tablets.
  • Is more effective than over-the-counter options for diarrhea and works very fast.
  • Most people who take Imodium feel there's no hassle and it's definitely worth it!
  • Non-habit forming and available over-the-counter.
  • It comes in caplets, liquid, and chewable tablets so you can use it anywhere you need it.
  • Imodium is used for short-term, chronic and traveler's diarrhea. It's also used for people who have diarrhea caused by cancer or certain medicines that treat cancer.
  • May have to take this medication 3 to 4 times a day for full effect.
  • Cannot use if you have diarrhea caused by an infection, or if you have ulcerative colitis or jaundice.
  • Children less than 6 years old are more vulnerable to serious side effects of Lomotil (diphenoxylate / atropine) including slowed breathing, coma, and delirium.
  • Imodium only treats your diarrhea symptoms. Diarrhea may be caused by a number of conditions and will need specific treatment that deals with the underlying issue.
  • Studies in people taking Imodium for chronic diarrhea showed if the maximum number of doses didn't relieve symptoms in 10 days, then it probably won't work for that condition. You can talk to your doctor about other treatment options.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
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285 reviews so far
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Side effects
The Lomotil (diphenoxylate / atropine) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Constipation
See more detailed side effects
Risks and risk factors
  • Dehydration
    • Taking diuretics
    • Not drinking enough fluids
    • Severe diarrhea
  • Sleepiness and dizziness
    • Other medications that make you drowsy
  • Coma and behavior problems
    • Liver problems
  • Serious bowel problems
    • Ulcerative colitis
  • Overdosage or dependence
See more detailed risks and warnings
  • Allergic reactions
    • Allergy to loperamide
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Liver problems
    • Current liver problems
  • Serious intestinal problems
    • Taking HIV medicines
    • Active infectious colitis
  • Risk to fetus
    • Women of childbearing age
See more detailed risks and warnings