Compare loxapine vs. perphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Loxitane (loxapine)

Prescription only

Trilafon (perphenazine)

Prescription only
Treats schizophrenia.

Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.

Treats schizophrenia.

Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.

Upsides
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
Downsides
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
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Dosage forms
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Reviews
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Side effects
The Loxitane (loxapine) FDA package insert doesn’t have numbers about how common side effects are.
The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of death
    • People age 65 and older with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Seizures
    • History of seizures
  • Vision changes
See more detailed risks and warnings
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Difficulty controlling movements
  • Higher risk for falls
  • Sleepiness
    • Drinking alcohol or taking narcotics
  • Higher risk of infection
See more detailed risks and warnings