Compare loxapine vs. thioridazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Loxitane (loxapine)

Prescription only

Mellaril (thioridazine)

Prescription only
Treats schizophrenia.

Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.

Treats schizophrenia.

Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.

Upsides
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
Downsides
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
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Reviews
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Side effects
The Loxitane (loxapine) FDA package insert doesn’t have numbers about how common side effects are.
The Mellaril (thioridazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of death
    • People age 65 and older with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Seizures
    • History of seizures
  • Vision changes
See more detailed risks and warnings
  • Problems with the heartbeat
    • History of heartbeat problems
    • Taking medicines for depression
    • Taking beta blockers
  • Increased risk of death in elderly people with dementia
    • People older than 65 years with dementia and psychosis
  • Difficulty controlling movements
    • Long-term use of Mellaril (thioridazine)
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Sleepiness and risk of falls
    • Drinking alcohol or taking narcotics
  • Decreased white blood cells
    • History of low white blood cells
See more detailed risks and warnings