Compare loxapine vs. trifluoperazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Loxitane (loxapine)

Prescription only
Treats schizophrenia.

Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.

Treats anxiety and schizophrenia.

Stelazine (trifluoperazine) can be used to treat schizophrenia, but you might have trouble controlling your movements.

Upsides
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
  • Stelazine (trifluoperazine) is one of the recommended medicines for schizophrenia.
  • It’s approved in children age 6 and older.
  • Available in generic.
  • Compared to other similar medicines, you're less likely to feel dehydrated or have problems with your heart with Stelazine (trifluoperazine).
Downsides
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
  • If you take Stelazine (trifluoperazine) for more than 12 weeks or are taking high doses of Stelazine (trifluoperazine), you’re at a higher risk for being unable to control your movements.
  • Stelazine (trifluoperazine) can cause agitation and trouble sleeping. These symptoms can sometimes disappear, or there are other treatments you can take to help.
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Reviews
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Side effects
The Loxitane (loxapine) FDA package insert doesn’t have numbers about how common side effects are.
The Stelazine (trifluoperazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of death
    • People age 65 and older with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Seizures
    • History of seizures
  • Vision changes
See more detailed risks and warnings
  • Higher risk of death in people age 65 and older with dementia
    • People age 65 and older with dementia and psychosis
  • Difficulty controlling movements
    • Women age 65 and older
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Changes in blood cell counts
    • History of low white or red blood cell counts
  • Liver damage
  • Low blood pressure and higher risk of falls
See more detailed risks and warnings