Compare Lunesta vs. Hetlioz

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lunesta (Eszopiclone)

Prescription only

Hetlioz (tasimelteon)

Prescription only
Helps you sleep.

Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.

3.3/ 5 average rating with 592 reviewsforLunesta
Keeps the sleep cycle normal for completely blind people who aren't able to see light.

Hetlioz (tasimelteon) is the only approved medicine to help completely blind people who are unable to see light maintain regular sleep cycles. It is only available as a brand name, so it can be expensive.

Upsides
  • Effective at helping people fall asleep faster and sleep longer.
  • Not as habit-forming, so you can use it for longer than most other sleep medicines.
  • Hetlioz (tasimelteon) is not addictive.
  • Hetlioz (tasimelteon) is the only drug that's approved to help people unable to see light to have regular sleep cycles.
  • If you have to stop taking Hetlioz (tasimelteon) suddenly, you're not likely to have withdrawal.
Downsides
  • More likely to cause withdrawal symptoms if you stop taking it suddenly.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
  • Hetlioz (tasimelteon) can take weeks to months for you to notice any effect.
  • Hetlioz (tasimelteon) is only available as a brand name so it can be expensive.
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Used for
  • Non-24 hour sleep-wake cycle
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$14445.07
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Reviews
592 reviews so far
55%
saidit'sworth it
36%
saiditworked well
17%
saidit'sa big hassle

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Side effects
10possible side effects
  • Headache
    15%
  • Unpleasant Taste
    8%
  • Dyspepsia
    6%
  • Pain
    4%
  • Diarrhea
    4%
  • Pruritus
    4%
  • Dry Mouth
    3%
  • Abnormal Dreams
    3%
  • Neuralgia
    3%
  • Urinary Tract Infection
    3%
See more detailed side effects
5possible side effects
  • Headache
    17%
  • Abnormal liver tests
    10%
  • Nightmares or abnormal dreams
    10%
  • Common cold or flu
    7%
  • Urinary tract infection
    7%
See more detailed side effects
Risks and risk factors
  • Dependence and withdrawal
    • Continuous use for 2 weeks or more
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
    • Less than 7 hours of sleep.
  • Abnormal thoughts
    • Undiagnosed psychiatric conditions
  • Sleep driving
    • Taking with alcohol or drugs that acts in the brain
  • Serious allergic reactions
  • Risk of falls and injury
    • Elderly
    • Higher dose
    • Liver problems
    • Taking Lunesta (Eszopiclone) with other nervous system depressants
    • Long-term use
  • Risk to fetus
    • Women of childbearing age
    • Breast-feeding
See more detailed risks and warnings