Compare Lyrica vs. Cymbalta
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats pain caused by nerve damage and prevents seizures.
Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.
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3.3/ 5 average rating with 66 reviewsforLyrica
Improves mood and relieves certain types of pain.
Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.
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3.6/ 5 average rating with 496 reviewsforCymbalta
Upsides
- Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
- It is less habit forming than narcotics.
- It can also be used in combination with other anti-seizure medicines to treat epilepsy.
- Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
- Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
- Available as a generic, which is cheaper.
Downsides
- Likely expensive since it is not available in generic versions.
- Has a higher risk than other pain medicines to affect your heart rate or rhythm.
- Requires adjustment in dose if you have lower kidney function.
- Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
- Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
- Cymbalta (duloxetine) can increase high blood pressure.
- Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
Used for
- Nerve pain
- Fibromyalgia
- Seizures
- Anxiety
- Restless leg syndrome
- Depression
- Anxiety
- Diabetic neuropathy (nerve damage)
- Fibromyalgia
- Chronic muscle pain
- Urinary incontinence (women)
Dosage forms
- Pill
- Liquid
- Pill
- Extended release
Price
Lowest price
$506.15
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$12.40
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Reviews
66 reviews so far
47%
saidit'sworth it
42%
saiditworked well
32%
saidit'sa big hassle
Have you used Lyrica (pregabalin)?
Leave a review496 reviews so far
58%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle
Have you used Cymbalta (duloxetine)?
Leave a reviewSide effects
28possible side effects
- Dizziness23%
- Drowsiness13%
- Headache11%
- Blurry vision8%
- Weight gain8%
- Dry mouth7%
- Fatigue5%
- Swelling of the hands and feet5%
- Constipation4%
- Sinus infection4%
- Increased appetite4%
- Joint pain4%
- Loss of focus4%
- Feeling off balance2%
- Vomiting2%
- Abdominal distension2%
- Chest pain2%
- Fluid retention2%
- Muscle spasms2%
- Back pain2%
- Balance disorder2%
- Abnormal coordination2%
- Partial loss of sensitivity to touch2%
- Lethargy2%
- Intense feeling of happiness2%
- Anxiety2%
- Depression2%
- Sore throat2%
12possible side effects
- Nausea23%
- Headache14%
- Dry mouth13%
- Drowsiness10%
- Fatigue9%
- Difficulty sleeping9%
- Constipation9%
- Dizziness9%
- Diarrhea9%
- Decreased appetite7%
- Excessive sweating6%
- Abdominal pain5%
Risks and risk factors
- Suicidal thoughts or behavior
- Starting Lyrica (pregabalin) or changing doses
- Driving impairment
- Taking Lyrica (pregabalin) with alcohol
- Taking other medicines that make you drowsy
- Giant hives (angioedema)
- History of unusual swelling (angioedema)
- Taking other medications (ie. lisinopril) that can cause angioedema
- Heart problems
- History of cardiovascular disease
- Swelling of the hands and feet
- Taking with certain diabetes medications
- Withdrawal symptoms
- Stopping Lyrica (pregabalin) suddenly
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
- Withdrawal
- Stopping Cymbalta (duloxetine) abruptly
- Increased bleeding
- Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
- Changes in blood pressure and risk of falls
- Elderly patients
- History of gait disturbances
- Taking more than 60 mg of Cymbalta (duloxetine) daily
- Taking other medicines that lower blood pressure
- History of high blood pressure
- Bipolar disorder
- History of bipolar disorder
- At risk for bipolar disorder