Compare Lyrica vs. lidocaine
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats pain caused by nerve damage and prevents seizures.
Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.
3.3/ 5 average rating with 66 reviewsforLyrica
Treats nerve pain.
Lidoderm (lidocaine) works well to treat nerve pain that is localized to a small area, but its topical application may cause minor skin irritation.
4.2/ 5 average rating with 18 reviewsforlidocaine
- Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
- It is less habit forming than narcotics.
- It can also be used in combination with other anti-seizure medicines to treat epilepsy.
- Minimal side-effects compared to other pain relievers since it works locally at the site of application.
- Won't hurt your kidneys or liver unlike other pain relievers.
- Available in many different topical formulations to fit your needs.
- Likely expensive since it is not available in generic versions.
- Has a higher risk than other pain medicines to affect your heart rate or rhythm.
- Requires adjustment in dose if you have lower kidney function.
- Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
- Application may cause minor stinging or burning skin irritation.
- Used patches requires proper medication disposal since it still contain enough medicine to be dangerous to children and pets.
- Not a good choice if you've had allergic reactions to numbing medications (local anesthetics) or have a history of irregular heartbeats.
- Nerve pain
- Restless leg syndrome
- Local anesthesia
- Nerve pain from shingles
- Topical solution
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66 reviews so far
saidit'sa big hassle
Have you used Lyrica (pregabalin)?Leave a review
18 reviews so far
saidit'sa big hassle
Have you used Lidoderm (lidocaine)?Leave a review
28possible side effects
- Blurry vision8%
- Weight gain8%
- Dry mouth7%
- Swelling of the hands and feet5%
- Sinus infection4%
- Increased appetite4%
- Joint pain4%
- Loss of focus4%
- Feeling off balance2%
- Abdominal distension2%
- Chest pain2%
- Fluid retention2%
- Muscle spasms2%
- Back pain2%
- Balance disorder2%
- Abnormal coordination2%
- Partial loss of sensitivity to touch2%
- Intense feeling of happiness2%
- Sore throat2%
The Lidoderm (lidocaine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Suicidal thoughts or behavior
- Starting Lyrica (pregabalin) or changing doses
- Driving impairment
- Taking Lyrica (pregabalin) with alcohol
- Taking other medicines that make you drowsy
- Giant hives (angioedema)
- History of unusual swelling (angioedema)
- Taking other medications (ie. lisinopril) that can cause angioedema
- Heart problems
- History of cardiovascular disease
- Swelling of the hands and feet
- Taking with certain diabetes medications
- Withdrawal symptoms
- Stopping Lyrica (pregabalin) suddenly
- Use of heating pad on skin
- Applying patch to red, irritated or broken skin
- Leaving patch on for more than 12 hours
- Using patch on a very large area
- Older age
- Smaller patients
- Liver disease
- Accidental poisoning
- Not disposing of Lidoderm (lidocaine) correctly
- Eye irritation
- Not washing hands after touching or applying Lidoderm (lidocaine)
- Skin reactions
- Applying Lidoderm (lidocaine) to warm skin
- Covering patch with wrap or heating pad
- Heart problems
- History of heart problems
- Using Lidoderm (lidocaine) with medications to treat irregular heartbeat