Compare Lyrica vs. Pristiq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lyrica (pregabalin)

Prescription only

Pristiq (Desvenlafaxine)

Prescription only
Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

3.3/ 5 average rating with 66 reviewsforLyrica
Improves mood.

Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.

3.5/ 5 average rating with 196 reviewsforPristiq
Upsides
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
  • Effective at relieving symptoms and lowering relapse rates for depression.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
  • Similar to Effexor, without any extra benefits in clinical studies.
  • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
  • Not available in generic form, so it's more expensive.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Extended release
Price
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Reviews
66 reviews so far
47%
saidit'sworth it
42%
saiditworked well
32%
saidit'sa big hassle

Have you used Lyrica (pregabalin)?

Leave a review
196 reviews so far
53%
saidit'sworth it
49%
saiditworked well
23%
saidit'sa big hassle

Have you used Pristiq (Desvenlafaxine)?

Leave a review
Side effects
28possible side effects
  • Dizziness
    23%
  • Drowsiness
    13%
  • Headache
    11%
  • Blurry vision
    8%
  • Weight gain
    8%
  • Dry mouth
    7%
  • Fatigue
    5%
  • Swelling of the hands and feet
    5%
  • Constipation
    4%
  • Sinus infection
    4%
  • Increased appetite
    4%
  • Joint pain
    4%
  • Loss of focus
    4%
  • Feeling off balance
    2%
  • Vomiting
    2%
  • Abdominal distension
    2%
  • Chest pain
    2%
  • Fluid retention
    2%
  • Muscle spasms
    2%
  • Back pain
    2%
  • Balance disorder
    2%
  • Abnormal coordination
    2%
  • Partial loss of sensitivity to touch
    2%
  • Lethargy
    2%
  • Intense feeling of happiness
    2%
  • Anxiety
    2%
  • Depression
    2%
  • Sore throat
    2%
See more detailed side effects
17possible side effects
  • Nausea
    22%
  • Dizziness
    13%
  • Dry mouth
    11%
  • Hyperhidrosis
    10%
  • Constipation
    9%
  • Insomnia
    9%
  • Fatigue
    7%
  • Decreased appetite
    5%
  • Somnolence
    4%
  • Vomiting
    3%
  • Anxiety
    3%
  • Vision blurred
    3%
  • Tremor
    2%
  • Abnormal dreams
    2%
  • Mydriasis
    2%
  • Vertigo
    2%
  • Tinnitus
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Starting Lyrica (pregabalin) or changing doses
  • Driving impairment
    • Taking Lyrica (pregabalin) with alcohol
    • Taking other medicines that make you drowsy
  • Giant hives (angioedema)
    • History of unusual swelling (angioedema)
    • Taking other medications (ie. lisinopril) that can cause angioedema
  • Heart problems
    • History of cardiovascular disease
  • Swelling of the hands and feet
    • Taking with certain diabetes medications
  • Withdrawal symptoms
    • Stopping Lyrica (pregabalin) suddenly
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Withdrawal
    • Stopping Pristiq (Desvenlafaxine) suddenly
  • High blood pressure
    • History of high blood pressure
  • Increased bleeding
    • Taking other blood-thinning drugs
  • Sexual dysfunction
  • Mania
    • History of bipolar disorder
    • At risk for bipolar disorder
See more detailed risks and warnings