Compare Lyrica vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lyrica (pregabalin)

Prescription only

Remeron (mirtazapine)

Prescription only
Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

3.3/ 5 average rating with 66 reviewsforLyrica
Improves mood.

Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.

3.3/ 5 average rating with 152 reviewsforRemeron
Upsides
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
Downsides
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
Price
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Reviews
66 reviews so far
47%
saidit'sworth it
42%
saiditworked well
32%
saidit'sa big hassle

Have you used Lyrica (pregabalin)?

Leave a review
152 reviews so far
45%
saidit'sworth it
39%
saiditworked well
26%
saidit'sa big hassle

Have you used Remeron (mirtazapine)?

Leave a review
Side effects
28possible side effects
  • Dizziness
    23%
  • Drowsiness
    13%
  • Headache
    11%
  • Blurry vision
    8%
  • Weight gain
    8%
  • Dry mouth
    7%
  • Fatigue
    5%
  • Swelling of the hands and feet
    5%
  • Constipation
    4%
  • Sinus infection
    4%
  • Increased appetite
    4%
  • Joint pain
    4%
  • Loss of focus
    4%
  • Feeling off balance
    2%
  • Vomiting
    2%
  • Abdominal distension
    2%
  • Chest pain
    2%
  • Fluid retention
    2%
  • Muscle spasms
    2%
  • Back pain
    2%
  • Balance disorder
    2%
  • Abnormal coordination
    2%
  • Partial loss of sensitivity to touch
    2%
  • Lethargy
    2%
  • Intense feeling of happiness
    2%
  • Anxiety
    2%
  • Depression
    2%
  • Sore throat
    2%
See more detailed side effects
17possible side effects
  • Sleepiness
    54%
  • Dry mouth
    25%
  • Increased appetite  
    17%
  • Increased appetite
    17%
  • Constipation
    13%
  • Weight gain
    12%
  • Lack of energy
    8%
  • Dizziness
    7%
  • Flu syndrome
    5%
  • Abnormal dreams
    4%
  • Abnormal thinking
    3%
  • Back pain
    2%
  • Swelling in limbs
    2%
  • Muscle pain
    2%
  • Tremor
    2%
  • Confusion
    2%
  • Urinary frequency
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Starting Lyrica (pregabalin) or changing doses
  • Driving impairment
    • Taking Lyrica (pregabalin) with alcohol
    • Taking other medicines that make you drowsy
  • Giant hives (angioedema)
    • History of unusual swelling (angioedema)
    • Taking other medications (ie. lisinopril) that can cause angioedema
  • Heart problems
    • History of cardiovascular disease
  • Swelling of the hands and feet
    • Taking with certain diabetes medications
  • Withdrawal symptoms
    • Stopping Lyrica (pregabalin) suddenly
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Heart problems
    • History of heart problems
    • History of liver problems
    • Higher dose
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
  • Weight gain
  • Blood disorders
See more detailed risks and warnings