Compare Lyrica vs. Wellbutrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lyrica (pregabalin)

Prescription only

Wellbutrin (Bupropion)

Prescription only
Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

3.3/ 5 average rating with 66 reviewsforLyrica
Improves mood.

Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.

3.4/ 5 average rating with 1164 reviewsforWellbutrin
Upsides
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Extended release
Price
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Reviews
66 reviews so far
47%
saidit'sworth it
42%
saiditworked well
32%
saidit'sa big hassle

Have you used Lyrica (pregabalin)?

Leave a review
1164 reviews so far
60%
saidit'sworth it
40%
saiditworked well
13%
saidit'sa big hassle

Have you used Wellbutrin (Bupropion)?

Leave a review
Side effects
28possible side effects
  • Dizziness
    23%
  • Drowsiness
    13%
  • Headache
    11%
  • Blurry vision
    8%
  • Weight gain
    8%
  • Dry mouth
    7%
  • Fatigue
    5%
  • Swelling of the hands and feet
    5%
  • Constipation
    4%
  • Sinus infection
    4%
  • Increased appetite
    4%
  • Joint pain
    4%
  • Loss of focus
    4%
  • Feeling off balance
    2%
  • Vomiting
    2%
  • Abdominal distension
    2%
  • Chest pain
    2%
  • Fluid retention
    2%
  • Muscle spasms
    2%
  • Back pain
    2%
  • Balance disorder
    2%
  • Abnormal coordination
    2%
  • Partial loss of sensitivity to touch
    2%
  • Lethargy
    2%
  • Intense feeling of happiness
    2%
  • Anxiety
    2%
  • Depression
    2%
  • Sore throat
    2%
See more detailed side effects
29possible side effects
  • Agitation
    32%
  • Dry mouth
    28%
  • Constipation
    26%
  • Headache/migraine
    26%
  • Nausea/vomiting
    23%
  • Dizziness
    22%
  • Excessive sweating
    22%
  • Tremor
    21%
  • Sleepiness
    20%
  • Insomnia
    19%
  • Blurred vision
    15%
  • Tachycardia
    11%
  • Confusion
    8%
  • Rash
    8%
  • Hostility
    6%
  • Auditory disturbance
    5%
  • Menstrual complaints
    5%
  • Cardiac arrhythmias
    5%
  • Impaired sleep quality
    4%
  • Sensory disturbance
    4%
  • Appetite increase
    4%
  • Palpitations
    4%
  • Hypertension
    4%
  • Impotence
    3%
  • Anxiety
    3%
  • Decreased libido
    3%
  • Gustatory disturbance
    3%
  • Dyspepsia
    3%
  • Hypotension
    3%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Starting Lyrica (pregabalin) or changing doses
  • Driving impairment
    • Taking Lyrica (pregabalin) with alcohol
    • Taking other medicines that make you drowsy
  • Giant hives (angioedema)
    • History of unusual swelling (angioedema)
    • Taking other medications (ie. lisinopril) that can cause angioedema
  • Heart problems
    • History of cardiovascular disease
  • Swelling of the hands and feet
    • Taking with certain diabetes medications
  • Withdrawal symptoms
    • Stopping Lyrica (pregabalin) suddenly
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Psychiatric effects for smoking cessation
    • History of depression
    • History of bipolar disorder
    • At risk for bipolar disorder
    • Withdrawing from nicotine
  • Seizures
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
  • Mania
    • History of bipolar disorder
    • At risk for bipolar disorder
  • Increased side effects
    • Current kidney problems
    • Current liver problems
  • Weight loss
See more detailed risks and warnings