Compare maprotiline vs. doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Ludiomil (maprotiline)

Prescription only

doxepin

Prescription only
Stabilizes your mood.

While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.

Treats depression and anxiety.

doxepin can treat depression and anxiety, but it's not a first choice medication because of its many side effects.

Upsides
  • Ludiomil (maprotiline) is available in generic.
  • Ludiomil (maprotiline) doesn't cause sleep problems, unlike other medicines used to treat depression.
  • doxepin has been consistently shown to improve symptoms of depression and anxiety.
  • doxepin has been used to treat depression for over forty years.
Downsides
  • Ludiomil (maprotiline) can make you very drowsy compared to other similar medicines.
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
  • Stopping Ludiomil (maprotiline) suddenly without telling your doctor can be dangerous.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for several weeks.
  • doxepin can make you very sleepy. Try taking it at bedtime if you need to be alert during the day.
  • You shouldn't drink alcohol with doxepin. It can worsen side effects like drowsiness.
  • You have to take it daily, especially if you are feeling better, for the medicine to do its job.
  • It can have more side effects than other antidepressants, like weight gain and increased appetite, decreased libido, and sleepiness.
  • It's not unusual for people to try different antidepressants until they find one that works for them.
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Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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Side effects
12possible side effects
  • Dry mouth
    22%
  • Drowsiness
    16%
  • Dizziness
    8%
  • Constipation
    6%
  • Nervousness
    6%
  • Weakness & fatigue
    4%
  • Headache
    4%
  • Vision changes
    4%
  • Anxiety
    3%
  • Difficulty controlling movements
    3%
  • Trouble sleeping
    2%
  • Nausea
    2%
See more detailed side effects
The doxepin FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of suicide
    • People under age 24
  • Possible bipolar disorder
  • Heart problems
    • History of heart attack or heart disease
  • Higher risk of infections
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or under
  • Unmasking of bipolar disorder
    • Bipolar disorder
  • Serotonin syndrome
    • Taking MAOIs (monoamine oxidase inhibitors)
  • Heart problems
    • History of heart disease
    • Adults over 65
    • Electrolyte imbalance
  • Sleepiness
    • Adults 65 years or older
    • Taking other medicines that cause drowsiness (antihistamines, sleep medications, narcotic pain medications)
    • Alcohol
  • Dizziness and falls
    • Age 65 years or older
See more detailed risks and warnings