Compare Medrol vs. Provigil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Provigil (modafinil)

Prescription only
Calms down your immune system.

Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.

3.7/ 5 average rating with 66 reviewsforMedrol
Improves alertness.

Provigil (modafinil) is effective in improving alertness, but it interacts with some medicines and shouldn't be used long-term.

4.2/ 5 average rating with 28 reviewsforProvigil
Upsides
  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
  • Provigil (modafinil) is a nonstimulant medication that improves alertness.
  • Provigil (modafinil) is available in a cheaper, generic version.
  • Provigil (modafinil) is good at decreasing excessive sleepiness in shift work sleep disorder.
  • If you need to sleep in the daytime, this medication won't effect you.
Downsides
  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
  • Provigil (modafinil) can be habit forming, so it shouldn't be used for long-term treatment.
  • Provigil (modafinil) is not a good choice if you have liver problems.
  • May not be a good option if you are taking hormonal contraception like birth control pills.
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Used for
  • Allergies
  • Skin conditions
  • Endocrine conditions
  • Eye conditions
  • Gastrointestinal conditions
  • Respiratory disorder
  • Multiple Sclerosis flare-up
  • Blood-related conditions
  • Drug-associated allergic reactions
  • Lupus
  • Cancer
  • Rheumatoid Arthritis
  • Juvenile Rheumatoid Arthritis
  • Severe Psoriasis
  • COPD episode
Dosage forms
  • Pill
  • Injection
  • Pill
Price
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Reviews
66 reviews so far
59%
saidit'sworth it
53%
saiditworked well
23%
saidit'sa big hassle

Have you used Medrol (methylprednisolone)?

Leave a review
28 reviews so far
82%
saidit'sworth it
71%
saiditworked well
4%
saidit'sa big hassle

Have you used Provigil (modafinil)?

Leave a review
Side effects
The Medrol (methylprednisolone) FDA package insert doesn’t have numbers about how common side effects are.
25possible side effects
  • Headache
    34%
  • Nausea
    11%
  • Nervousness
    7%
  • Stuffy nose
    7%
  • Back pain
    6%
  • Diarrhea
    6%
  • Indigestion
    5%
  • Difficulty sleeping
    5%
  • Anxiety
    5%
  • Dizziness
    5%
  • Flu symptoms
    4%
  • Dry mouth
    4%
  • Loss of appetite
    4%
  • Throat inflammation
    4%
  • Chest pain
    3%
  • High blood pressure
    3%
  • Fast heart beat
    2%
  • Palpitation
    2%
  • Dilation of blood vessels
    2%
  • Constipation
    2%
  • Abnormal liver function
    2%
  • Depression
    2%
  • Burning/tingling sensation
    2%
  • Drowsiness
    2%
  • Lung disorder
    2%
See more detailed side effects
Risks and risk factors
  • Weakened immune system response to stress
    • Taking high doses of Medrol (methylprednisolone) for a long period of time
    • Young children
    • Stress such as trauma, injury, or infection
  • Increased risk for infections
    • Taking other medicines that weaken the immune system
    • Taking Medrol (methylprednisolone) for a long time
    • Those who are not vaccinated against viral illnesses
    • Coming into contact with people who have viral illness
    • History of bacterial or viral conditions
  • Changes in heart and kidney function
    • Those who had a recent heart attack
    • History of heart failure, high blood pressure, and kidney problems
  • Eye problems
    • Those with cataracts and/or glaucoma
    • History of herpes simplex in the eye
  • Harm to fetus (unborn baby)
    • Pregnant women
    • Women who can or plan to become pregnant
See more detailed risks and warnings
  • Serious allergic reactions
    • Allergy to Provigil (modafinil)
  • Heart problems
    • History of heart problems
  • Increased side effects
    • Current kidney problems
    • Current liver problems
  • Driving impairment
    • Taking with alcohol or drugs
See more detailed risks and warnings