Compare Mefloquine vs. Plaquenil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats malaria and autoimmune conditions including rheumatoid arthritis and lupus.

Plaquenil (hydroxychloroquine) is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs.

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  • Plaquenil (hydroxychloroquine) has been shown to improve physical function in up to 80% of patients with rheumatoid arthritis. Plaquenil (hydroxychloroquine) is commonly used for lupus in children because of less side effects compared to other medications.
  • Plaquenil (hydroxychloroquine) helps minimize joint damage. It can also decrease symptoms and future complications.
  • Plaquenil (hydroxychloroquine) is a good choice for people who have difficulty tolerating newer biologic medications.
  • A generic form of Plaquenil (hydroxychloroquine) is available.
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  • You will likely have to take additional medications to keep your rheumatoid arthritis in control.
  • Some people may develop eye problems, so you’ll have to get your eyes checked often.
  • Depending on what you're being treated for, it can take up to 6 months for the full benefits of Plaquenil (hydroxychloroquine).
  • Many people have nausea, stomach cramps, and diarrhea when they first start taking Plaquenil (hydroxychloroquine).
  • If you have heart, eye, liver conditions, or psoriasis, talk to your doctor to see if Plaquenil (hydroxychloroquine) is right for you.
Used for
  • Malaria
  • Mild to moderate
  • Plasmodium falciparum or P vivax Malaria
  • Plasmodium falciparum or vivax; Prophylaxis
Dosage forms
  • Pill
  • Pill
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Side effects
The Lariam (Mefloquine) FDA package insert doesn’t have numbers about how common side effects are.
The Plaquenil (hydroxychloroquine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
No information currently available
  • Prescribing by Doctors
  • Drug resistance
  • Worsening of psoriasis
  • Pregnancy
    • Women of childbearing age
  • Damage to retina of eye
    • Higher doses
    • Kidney disease
    • Use for longer than 5 years
    • Current problems with vision
    • Use of certain drugs such as tamoxifen
  • Heart problems
    • Taking other medicines that cause disruptions in heart rhythm
    • Existing heart conditions
See more detailed risks and warnings