Compare metformin vs. Actos
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Lowers blood sugar.
Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.
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3.7/ 5 average rating with 938 reviewsformetformin
Lowers blood sugar.
Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.
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3.1/ 5 average rating with 175 reviewsforActos
Upsides
- Improves sugar control and lowers A1c levels as much as 2%.
- One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
- Doesn't cause weight gain.
- Rarely causes low blood sugar.
- Improves sugar control and lowers A1c levels by around 1%.
- Easily taken by mouth as a once a day pill.
- Prevents the harmful effects of high sugar levels on your organs.
- Rarely causes low blood sugar.
- Lower the risk of heart attack or stroke.
Downsides
- Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
- Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
- Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
- May take several weeks to lower blood sugar.
- Can cause weight gain.
- People with heart failure or history of bladder cancer shouldn't use this medicine.
- Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
- Raises the risk of bone fractures, especially for people who already have a risk for fractures.
Used for
- Type 2 diabetes
- Diabetes prevention
- Diabetes from pregnancy
- Obesity with high insulin
- Polycystic ovary syndrome
- Type 2 diabetes
- Prediabetes
- Diabetic nephropathy
- Atherosclerosis
- Polycystic ovarian syndrome
Dosage forms
- Pill
- Extended release pill
- Liquid
- Pill
Price
Lowest price
$12.75
Find instant savings near youLowest price
$14.38
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Reviews
938 reviews so far
65%
saidit'sworth it
46%
saiditworked well
16%
saidit'sa big hassle
Have you used Glucophage (metformin)?
Leave a review175 reviews so far
42%
saidit'sworth it
30%
saiditworked well
21%
saidit'sa big hassle
Have you used Actos (pioglitazone)?
Leave a reviewSide effects
7possible side effects
- Diarrhea53%
- Nausea/vomiting26%
- Gas12%
- Weakness9%
- Indigestion7%
- Stomach pain6%
- Headache6%
11possible side effects
- Low blood sugar27%
- Swelling27%
- Colds and flu13%
- Headache9%
- Heart failure8%
- Sinus infection6%
- Back pain6%
- Pain in arms and legs6%
- Muscle pain5%
- Sore throat5%
- Chest pain5%
Risks and risk factors
- Excess lactic acid in the blood
- Kidney problems
- Liver problems
- Congestive heart failure
- Using contrast dye for procedures
- Surgery
- Alcohol use
- Low vitamin B12 levels
- Heart failure
- Heart failure
- Fluid buildup
- Liver damage
- Current liver problems
- Bladder cancer
- History of bladder cancer
- Bone fracture
- Women
- Low blood sugar