Compare metformin vs. Avandia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Glucophage (metformin)

Prescription only

Avandia (rosiglitazone)

Prescription only
Lowers blood sugar.

Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.

3.7/ 5 average rating with 938 reviewsformetformin
Controls blood sugar.

Avandia (rosiglitazone) is a good medicine for controlling blood sugar that can be taken once daily, but it can cause weight gain.

Upsides
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
  • Avandia (rosiglitazone) effectively controls blood sugar levels, with a low risk of severely low blood sugar.
  • Can be taken with or without food.
Downsides
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
  • Not recommended as a first choice drug for lowering blood sugar because it has many side effects.
  • Avandia (rosiglitazone) may cause weight gain.
  • May not be good for people with heart or liver problems.
  • Not recommended in children under 18 years old.
  • Can cause ovulation in women who don't have regular periods.
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Used for
Dosage forms
  • Pill
  • Extended release pill
  • Liquid
  • Pill
Price
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Reviews
938 reviews so far
65%
saidit'sworth it
46%
saiditworked well
16%
saidit'sa big hassle

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Side effects
7possible side effects
  • Diarrhea
    53%
  • Nausea/vomiting
    26%
  • Gas
    12%
  • Weakness
    9%
  • Indigestion
    7%
  • Stomach pain
    6%
  • Headache
    6%
See more detailed side effects
15possible side effects
  • Upper respiratory tract infection
    10%
  • Bone fractures
    9%
  • Injury
    8%
  • Headache
    6%
  • Common cold
    6%
  • Water retention and swelling
    5%
  • Back pain
    5%
  • Joint pain
    5%
  • High blood sugar
    4%
  • Fatigue
    4%
  • High blood pressure
    4%
  • Sinus infection
    3%
  • Low blood sugar
    3%
  • Diarrhea
    3%
  • Anemia
    2%
See more detailed side effects
Risks and risk factors
  • Excess lactic acid in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low vitamin B12 levels
See more detailed risks and warnings
  • Fluid buildup
    • Heart failure
  • Low blood sugar
    • Changes in diet and exercise
    • Drinking alcohol
    • Taking other medicines for diabetes
    • Over age 65
    • Liver or kidney problems
  • Bone fractures
    • Women
  • Liver damage
  • Vision problems
    • Swelling in the arms and legs
  • Pregnancy
See more detailed risks and warnings