Compare metformin vs. Onglyza
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Lowers blood sugar.
Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.
●●●●●
3.7/ 5 average rating with 938 reviewsformetformin
Lowers blood sugar.
Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.
Upsides
- Improves sugar control and lowers A1c levels as much as 2%.
- One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
- Doesn't cause weight gain.
- Rarely causes low blood sugar.
- DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
- Does not cause weight gain.
- May be a good option for those with bad liver function.
- Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides
- Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
- Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
- Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
- Typically not first-choice treatment for diabetes.
- Only lowers A1C (average blood sugar over time) by ~0.5%.
- Risk for heart failure has not been seen in other medicines that work just like it.
- May be more expensive than other anti-diabetic medicines.
Used for
- Type 2 diabetes
- Diabetes prevention
- Diabetes from pregnancy
- Obesity with high insulin
- Polycystic ovary syndrome
Dosage forms
- Pill
- Extended release pill
- Liquid
- Pill
Price
Lowest price
$11.62
Find instant savings near youLowest price
$464.73
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
938 reviews so far
65%
saidit'sworth it
46%
saiditworked well
16%
saidit'sa big hassle
Have you used Glucophage (metformin)?
Leave a reviewNot enough review data.Leave a review
Side effects
7possible side effects
- Diarrhea53%
- Nausea/vomiting26%
- Gas12%
- Weakness9%
- Indigestion7%
- Stomach pain6%
- Headache6%
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Excess lactic acid in the blood
- Kidney problems
- Liver problems
- Congestive heart failure
- Using contrast dye for procedures
- Surgery
- Alcohol use
- Low vitamin B12 levels
- inflammation of the pancreas
- Alcoholism
- Elevated triglycerides
- History of pancreatitis
- Gallstones
- Heart failure
- History of heart failure
- Bad kidney function
- Low blood sugar (hypoglycemia)
- Alcohol
- Unexpected changes in diet
- Changes in amount of exercise
- Taking other anti-diabetic medications
- Severe allergic reactions
- Severe joint pain
- Fluid-filled blisters on the skin (bullous pemphigoid)