Compare metformin vs. Starlix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Glucophage (metformin)

Prescription only

Starlix (nateglinide)

Prescription only
Lowers blood sugar.

Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.

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3.7/ 5 average rating with 938 reviewsformetformin
Lowers blood sugar.

Starlix (nateglinide) can quickly lower your blood sugar, but needs to be timed with your meals.

Upsides
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
  • Can quickly lower blood sugar.
  • Good alternative if you have poor kidney function.
  • Can be safely used in people 65 and older.
  • Widely available in generic (cheaper) form.
Downsides
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
  • Take during mealtime.
  • May need to take as often as three times daily.
  • Can easily cause hypoglycemia (low blood sugar) if you don't maintain a consistent diet or exercise schedule.
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Used for
Dosage forms
  • Pill
  • Extended release pill
  • Liquid
  • Pill
Price
Lowest price
$10.74
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Lowest price
$30.15
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Reviews
938 reviews so far
65%
saidit'sworth it
46%
saiditworked well
16%
saidit'sa big hassle

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Side effects
7possible side effects
  • Diarrhea
    53%
  • Nausea/vomiting
    26%
  • Gas
    12%
  • Weakness
    9%
  • Indigestion
    7%
  • Stomach pain
    6%
  • Headache
    6%
See more detailed side effects
10possible side effects
  • Common cold
    11%
  • Back pain
    4%
  • Flu symptoms
    4%
  • Dizziness
    4%
  • Joint problems
    3%
  • Diarrhea
    3%
  • Accidental trauma
    3%
  • Inflammation of the airways
    3%
  • Coughing
    2%
  • Low blood sugar
    2%
See more detailed side effects
Risks and risk factors
  • Excess lactic acid in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low vitamin B12 levels
See more detailed risks and warnings
  • Low blood sugar (hypoglycemia)
    • Changes in meal pattern
    • Changes in how much exercise you do
    • Taking other antidiabetic medications
    • Bad liver or renal function
See more detailed risks and warnings
Learn more about Glucophage (metformin)
Learn more about Starlix (nateglinide)