Compare metformin vs. Tradjenta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Glucophage (metformin)

Prescription only

Tradjenta (linagliptin)

Prescription only
Lowers blood sugar.

Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.

3.7/ 5 average rating with 938 reviewsformetformin
Lowers blood sugar.

Tradjenta (linagliptin) is good add-on medicine for controlling your blood sugar, but may cause body aches.

Upsides
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
  • Good add-on medicine if your blood sugars are still not controlled
  • Good option if you have bad liver or kidney function.
  • Can be taken once daily.
  • Does not cause weight gain.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
  • Not first-choice anti-diabetes medicine because it doesn't lower blood sugar levels as much as others.
  • Available as brand only and may be expensive
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Used for
Dosage forms
  • Pill
  • Extended release pill
  • Liquid
  • Pill
Price
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Reviews
938 reviews so far
65%
saidit'sworth it
46%
saiditworked well
16%
saidit'sa big hassle

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Side effects
7possible side effects
  • Diarrhea
    53%
  • Nausea/vomiting
    26%
  • Gas
    12%
  • Weakness
    9%
  • Indigestion
    7%
  • Stomach pain
    6%
  • Headache
    6%
See more detailed side effects
6possible side effects
  • Back pain
    9%
  • Joint pain
    8%
  • Lung infection
    8%
  • Headache
    6%
  • Cough
    6%
  • Pain in the limbs
    5%
See more detailed side effects
Risks and risk factors
  • Excess lactic acid in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low vitamin B12 levels
See more detailed risks and warnings
  • Inflammation of pancreas (pancreatitis)
    • Alcoholism
    • Elevated triglycerides
    • History of pancreatitis
  • Low blood sugar (hypoglycemia)
    • Alcoholism
    • Exercising more than you usually do
    • Insulin
    • Other antidiabetic medications
  • Severe allergic reactions
  • Severe joint pain
  • Fluid-filled blisters on the skin (bullous pemphigoid)
See more detailed risks and warnings