Compare methadone vs. fentanyl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Methadose (methadone)

Prescription only

Duragesic (fentanyl)

Prescription only
Treats severe pain or drug dependence.

Methadose (methadone) is a cheap and effective treatment for severe chronic pain, but has serious risks for fatal overdose and drug dependence.

Treats severe pain.

Duragesic (fentanyl) is an excellent pain reliever, but should only be used by people who've tried other opioid pain medications and still need more relief.

4.2/ 5 average rating with 84 reviewsforfentanyl
Upsides
  • Available as a cheap, generic version.
  • One of the stronger opioid medicines for treatment of severe pain.
  • Can also be used to treat opioid dependence as part of a complete recovery program.
  • Duragesic (fentanyl) is stronger than morphine, works quickly, and doesn't cause as many stomach problems.
  • It's available in many dosage forms, including a patch, injection, film, nasal spray, and lollipop.
  • The Duragesic (fentanyl) patch provides long-term pain relief and lowers the number of times you need to take pain medications each day.
Downsides
  • Methadose (methadone) can cause slowed breathing, coma, and death from overdose, especially if mixed with alcohol, sleeping pills, or muscle relaxants.
  • Constipation is a common side effect of Methadose (methadone) and you might need laxatives or stool softeners.
  • Not a good option for short-term pain relief.
  • Duragesic (fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • The patch doesn't provide quick pain relief.
  • Often causes drowsiness and constipation. If taking long-term, use a stool softener.
  • Shouldn't be used by people with breathing problems (like asthma and COPD), a slow heart rate, or are elderly.
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Patch
  • Dissolving tablet
  • Mouth spray
  • Lozenge
  • Buccal tablet
  • Nasal spray
Price
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Reviews
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84 reviews so far
79%
saidit'sworth it
70%
saiditworked well
14%
saidit'sa big hassle

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Side effects
The Methadose (methadone) FDA package insert doesn’t have numbers about how common side effects are.
34possible side effects
  • Vomiting
    34%
  • Nausea
    24%
  • Dizziness
    17%
  • Drowsiness
    17%
  • Headache
    16%
  • Constipation
    13%
  • Diarrhea
    13%
  • Itchy skin
    13%
  • Weakness
    9%
  • Abdominal pain
    9%
  • Difficulty sleeping
    6%
  • Rash
    6%
  • Swelling in the limbs
    5%
  • Confusion
    4%
  • Difficulty breathing
    4%
  • Upper abdominal pain
    4%
  • Loss of appetite
    4%
  • Anxiety
    4%
  • Tremor
    3%
  • Hypersensitivity
    3%
  • Urinary retention
    3%
  • Sweating
    3%
  • Accidental injury
    2%
  • Abnormal gait
    2%
  • Dry mouth
    2%
  • Nervousness
    2%
  • Dilation of blood vessels
    2%
  • Abnormal vision
    2%
  • Burning/pricking sensation
    2%
  • Confusional state
    2%
  • Fatigue
    2%
  • Muscle spasms
    2%
  • Depression
    2%
  • Hallucination
    2%
See more detailed side effects
Risks and risk factors
  • Death from lack of oxygen to the body (respiratory depression)
    • Start of treatment
    • Age 65 or greater
    • Dose changes and higher doses
  • Heart problems (arrhythmia)
    • History of cardiovascular disease
  • Driving impairment
    • Taking Methadose (methadone) with alcohol
    • Taking other medicines that make you less alert
  • Death from overdose
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Methadose (methadone)
  • Abuse, tolerance, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse or mental illness
See more detailed risks and warnings
  • Slowed breathing (respiratory depression)
    • Taking other medicines that interact with Duragesic (fentanyl)
    • Age 65 or greater
    • Taking benzodiazepines, other opioids, and/or alcohol
    • Asthma or COPD
  • Death from overdose
    • Children age 18 and younger
  • Death in newborn babies from opioid withdrawal
    • Long-term use of Duragesic (fentanyl) during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Medication errors
See more detailed risks and warnings