Compare methotrexate vs. chloroquine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT

Otrexup (methotrexate)

Prescription only

chloroquine

Prescription only
Reduces inflammation and cell replication.

Otrexup (methotrexate) is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.

Prevents and treats malaria, and also treats a type of bowel infection.

Effectively prevents and treats malaria, and treats a certain type of intestinal infection but can cause serious side effects in certain people.

Upsides
  • Otrexup (methotrexate) is available as an affordable generic form.
  • Otrexup (methotrexate) comes as a tablet, an injection that you give yourself, or an infusion that you get in the doctor's office or infusion center.
  • chloroquine is generally safe to use during pregnancy and for children.
  • You can take chloroquine with or without food.
Downsides
  • You may need frequent blood tests for monitoring when taking Otrexup (methotrexate).
  • Otrexup (methotrexate) can cause serious birth defects so women should avoid getting pregnant for at least 6 month and men 3 months after taking it.
  • While on Otrexup (methotrexate), you should avoid alcohol and staying out in the sun for too long.
  • chloroquine needs to be taken 1-2 weeks before traveling to an area with malaria, compared to some alternatives that can be taken 1-2 days before.
  • chloroquine is only effective against malaria from certain areas of the world.
  • chloroquine may worsen psoriasis, seizures, hearing problems, and liver conditions.
ADVERTISEMENT
Used for
Dosage forms
  • Pill
  • Injection
  • Liquid
  • Pill
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
4possible side effects
  • Abnormal liver function tests
    14%
  • Nausea, vomiting, diarrhea
    11%
  • Mouth inflammation and sores
    2%
  • Low white blood count
    2%
See more detailed side effects
The chloroquine FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Bone marrow suppression
  • Worsening side-effects
    • Reduced kidney function
    • fluid in the abdomen
    • fluid in the lungs
  • Use of NSAIDs
    • NSAIDS
    • High dose of methotrexate
  • Liver problems
    • Long-term use
    • Psoriasis
  • Lung problems
  • Diarrhea and mouth sores
    • Taking Otrexup (methotrexate) with high-dose NSAIDs
  • Tumor lysis syndrome
    • Rapidly growing tumors
  • Skin reactions
  • Infections
  • White blood cell cancer
  • Skin and bone tissue deterioration
    • Radiotherapy
See more detailed risks and warnings
  • Heart problems
    • Heart problems
  • Muscle weakness
    • Long-term use
  • Low blood counts
    • G6PD (glucose-6-phosphate dehydrogenase) deficiency
  • Eye injury
    • Taking high dose of chloroquine
    • Long-term use
    • Taking tamoxifen
    • Low body weight
    • Kidney problems
  • Liver damage
    • Taking other drugs that affect the liver
    • Alcoholism
    • Liver conditions
  • Hearing damage
    • History of hearing problems
See more detailed risks and warnings