Compare minocycline vs. Clindesse

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Solodyn (minocycline)

Prescription only

Clindesse (clindamycin)

Prescription only
Treats bacterial infections.

Solodyn (minocycline) is effective in treating a variety of bacterial infections such as acne, but it can cause permanent tooth staining, especially in an unborn baby and those who are age 8 or younger.

4.0/ 5 average rating with 17 reviewsforminocycline
Treats bacterial vaginal infections with a single dose.

Clindesse (clindamycin) treats vaginal infections and is very easy to use.

Upsides
  • May be taken with or without food.
  • Solodyn (minocycline) is used in combination with other medications to treat severe acne.
  • Available as a generic form.
  • Solodyn (minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
  • Can be a good alternative treatment for certain infections when penicillin can't be used.
  • Very easy to use and works within a few days.
  • Generic available, so cost is lower.
  • Doesn't have many side effects.
  • You can stand up and walk around right after you use it, so you can use it at any time of day.
Downsides
  • It can make birth control pills less effective, so barrier methods of birth control like condoms or diaphragms should be used while on Solodyn (minocycline).
  • Can permanently discolor your teeth, mouth, gums and skin. This is more common for pregnant women in their last half of pregnancy, infants, and children 8 and younger.
  • Your skin may be more sensitive to the sun and your chances of getting sunburned are higher.
  • May cause dizziness and affect your driving ability.
  • Not a good option for pregnant women since it can slow down the bone development of a fetus (unborn baby).
  • Can cause yeast infections in some women.
  • After using Clindesse (clindamycin), must avoid sex and using tampons for 7 days.
  • Can very rarely cause severe diarrhea.
  • Cannot be used if you have bowel diseases like Crohn's disease or ulcerative colitis.
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Used for
Dosage forms
  • Pill
  • Extended-release pill
  • Cream
Price
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Reviews
17 reviews so far
53%
saidit'sworth it
59%
saiditworked well
18%
saidit'sa big hassle

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Side effects
The Solodyn (minocycline) FDA package insert doesn’t have numbers about how common side effects are.
5possible side effects
  • Yeast infection
    14%
  • Headache
    7%
  • Back pain
    5%
  • Constipation
    2%
  • Bladder infection
    2%
See more detailed side effects
Risks and risk factors
  • Yellowing of teeth
    • Age 8 or younger
    • Women in their last half of pregnancy
    • Infants
    • Using Solodyn (minocycline) for a long period of time
  • Decreased effectiveness of oral birth control pills
    • Using oral birth control pills
  • New infection
    • Using Solodyn (minocycline) for a long period of time
  • Sunburn
  • Harm to fetus (unborn baby)
    • Women who can potentially or want to become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Allergy alert
    • Known allergy to clindamycin
    • Known allergy to lincosamides
  • Severe diarrhea
    • History of Clostridium difficile-associated diarrhea
    • Crohn's disease
    • Ulcerative colitis
    • Regional enteritis
  • Weakened condoms and vaginal diaphragms
  • Safety in girls who haven't started puberty
See more detailed risks and warnings