Compare Mirapex vs. carbidopa / levodopa extended release

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps with movement problems.

Mirapex (pramipexole) is effective for Parkinson's disease or restless legs syndrome, but can cause extreme drowsiness that affects daily living.

Treats Parkinson's disease.

Sinemet CR (carbidopa / levodopa extended release) is the first choice treatment for Parkinson's disease.

Upsides
  • Mirapex (pramipexole) may be better for older people with Parkinson's since it causes fewer movement and mental changes than its alternatives.
  • Mirapex (pramipexole) comes in extended-release form to help reduce side effects and ease administration.
  • Available as a generic so it will be cheaper than similar brand medications.
  • Sinemet CR (carbidopa / levodopa extended release) is released over a long period of time in your body and can allow you to take fewer pills less frequently.
Downsides
  • Mirapex (pramipexole) can be used by itself, but is usually used in combination with other medications to treat Parkinson's.
  • Not the best choice if you have kidney problems.
  • You cannot suddenly stop taking Mirapex (pramipexole) if you have been taking it for a long time.
  • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
  • Sinemet CR (carbidopa / levodopa extended release) will lose its effect over time. If you notice it wearing off sooner than you'd like, talk to your doctor.
  • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release
Price
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Reviews
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Side effects
36possible side effects
  • Postural hypotension
    53%
  • Muscle rigidity
    47%
  • Extrapyramidal syndrome
    28%
  • Insomnia
    27%
  • Dizziness
    26%
  • Hallucinations
    17%
  • Accidental injury
    17%
  • Dream abnormalities
    11%
  • Confusion
    10%
  • Muscle weakness
    10%
  • Constipation
    10%
  • Sleepiness
    9%
  • Muscle problems
    8%
  • Gait abnormalities
    7%
  • Muscle tenseness
    7%
  • Dry mouth
    7%
  • Memory loss
    6%
  • Urinary frequency
    6%
  • General swelling
    4%
  • Urinary tract infection
    4%
  • Shortness of breath
    4%
  • Accomodation abnormalities
    4%
  • Restlessness
    3%
  • Thinking abnormalities
    3%
  • Chest pain
    3%
  • Malaise
    3%
  • Runny nose
    3%
  • Vision abnormalities
    3%
  • Arthritis
    3%
  • Paranoid reaction
    2%
  • Urinary incontinence
    2%
  • Lung infection
    2%
  • Twitching
    2%
  • Swelling of joints
    2%
  • Peripheral swelling
    2%
  • Skin disorders
    2%
See more detailed side effects
15possible side effects
  • Difficulty controlling movements
    17%
  • Nausea
    6%
  • Hallucinations
    4%
  • Confusion
    4%
  • Dizziness
    3%
  • Depression
    2%
  • Urinary tract infection
    2%
  • Headache
    2%
  • Unusual dreams
    2%
  • Muscle spasms
    2%
  • Vomiting
    2%
  • Upper respiratory infection
    2%
  • Shortness of breath
    2%
  • Periods of immobility
    2%
  • Back pain
    2%
See more detailed side effects
Risks and risk factors
  • Impulse control problems
  • Problems with concentration
    • Taking with alcohol
    • Taking other medicines that make you sleepy
    • Sleep disorders
  • Low blood pressure
    • Taking blood pressure medicines
  • Kidney problems
    • Kidney problems
  • Skin cancer
    • Parkinson's disease
  • Hallucinations and behavior changes
    • Age 65 years or older
    • History of psychosis
    • Advanced Parkinson's disease
See more detailed risks and warnings
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • High fever and confusion
    • Stopping Sinemet CR (carbidopa / levodopa extended release) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Changes in blood pressure and falls
See more detailed risks and warnings